Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates.
Cereb Cortex
; 33(9): 5075-5081, 2023 04 25.
Article
in En
| MEDLINE
| ID: mdl-36197324
ABSTRACT
It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aging
/
Individuality
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Cereb Cortex
Journal subject:
CEREBRO
Year:
2023
Document type:
Article
Affiliation country:
Suecia