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Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates.
Nyberg, Lars; Andersson, Micael; Lundquist, Anders; Baaré, William F C; Bartrés-Faz, David; Bertram, Lars; Boraxbekk, Carl-Johan; Brandmaier, Andreas M; Demnitz, Naiara; Drevon, Christian A; Duezel, Sandra; Ebmeier, Klaus P; Ghisletta, Paolo; Henson, Richard; Jensen, Daria E A; Kievit, Rogier A; Knights, Ethan; Kühn, Simone; Lindenberger, Ulman; Plachti, Anna; Pudas, Sara; Roe, James M; Madsen, Kathrine Skak; Solé-Padullés, Cristina; Sommerer, Yasmine; Suri, Sana; Zsoldos, Eniko; Fjell, Anders M; Walhovd, Kristine B.
Affiliation
  • Nyberg L; Department of Radiation Sciences (Radiology), Umeå University, 901 87 Umeå, Sweden.
  • Andersson M; Department of Integrative Medical Biology, Umeå University, 901 87 Umeå, Sweden.
  • Lundquist A; Umeå Center for Functional Brain Imaging, Umeå University, 901 87 Umeå, Sweden.
  • Baaré WFC; Center for Lifespan Changes in Brain and Cognition, University of Oslo, Department of Psychology, University of Oslo, 0373 Oslo, Norway.
  • Bartrés-Faz D; Department of Integrative Medical Biology, Umeå University, 901 87 Umeå, Sweden.
  • Bertram L; Umeå Center for Functional Brain Imaging, Umeå University, 901 87 Umeå, Sweden.
  • Boraxbekk CJ; Umeå Center for Functional Brain Imaging, Umeå University, 901 87 Umeå, Sweden.
  • Brandmaier AM; Department of Statistics, USBE, Umeå University, Umeå S-90187, Sweden.
  • Demnitz N; Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, 2650 Copenhagen, Denmark.
  • Drevon CA; Department of Medicine, Faculty of Medicine and Health Sciences, Institut de Neurociències, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.
  • Duezel S; Center for Lifespan Changes in Brain and Cognition, University of Oslo, Department of Psychology, University of Oslo, 0373 Oslo, Norway.
  • Ebmeier KP; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, 23562 Lübeck, Germany.
  • Ghisletta P; Department of Radiation Sciences (Radiology), Umeå University, 901 87 Umeå, Sweden.
  • Henson R; Umeå Center for Functional Brain Imaging, Umeå University, 901 87 Umeå, Sweden.
  • Jensen DEA; Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, 2650 Copenhagen, Denmark.
  • Kievit RA; Faculty of Medical and Health Sciences, Institute for Clinical Medicine, University of Copenhagen, 2400 Copenhagen, Denmark.
  • Knights E; Department of Neurology, Institute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital - Bispebjerg and Frederiksberg, 2400 Copenhagen, Denmark.
  • Kühn S; Center for Lifespan Psychology, Max Planck Institute for Human Development, 14195 Berlin, Germany.
  • Lindenberger U; MSB Medical School Berlin, 14197 Berlin, Germany.
  • Plachti A; Max Plank UCL Centre for Computational Psychiatry and Ageing Research, 14195 Berlin, Germany, and London, UK.
  • Pudas S; Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, 2650 Copenhagen, Denmark.
  • Roe JM; Vitas AS, Science Park, 0349 Oslo, Norway.
  • Madsen KS; Department of Nutrition, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo Norway.
  • Solé-Padullés C; Center for Lifespan Psychology, Max Planck Institute for Human Development, 14195 Berlin, Germany.
  • Sommerer Y; Department of Psychiatry, University of Oxford, OX3 7JX Oxford, UK.
  • Suri S; Faculty of Psychology and Educational Sciences, University of Geneva, 1204 Geneva, Switzerland.
  • Zsoldos E; UniDistance Suisse, 3900 Brig, Switzerland.
  • Fjell AM; Swiss National Centre of Competence in Research LIVES, University of Geneva, 1204 Geneva, Switzerland.
  • Walhovd KB; Medical Research Council Cognition and Brain Sciences Unit, Department of Psychiatry, University of Cambridge, Cambridge CB2 7EF, England.
Cereb Cortex ; 33(9): 5075-5081, 2023 04 25.
Article in En | MEDLINE | ID: mdl-36197324
ABSTRACT
It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Individuality Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cereb Cortex Journal subject: CEREBRO Year: 2023 Document type: Article Affiliation country: Suecia
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Individuality Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cereb Cortex Journal subject: CEREBRO Year: 2023 Document type: Article Affiliation country: Suecia