Diagnosis and Classification of Fistula from Inflammatory Bowel Disease and Inflammatory Bowel Disease-Related Surgery.
Gastrointest Endosc Clin N Am
; 32(4): 631-650, 2022 Oct.
Article
in En
| MEDLINE
| ID: mdl-36202507
ABSTRACT
Fistula in inflammatory bowel disease (IBD) is a well-known yet poorly understood phenotype. Pathophysiology is largely based on the activation of the epithelial-mesenchymal transition (EMT); however, interactions with the microbiome, genetics, mechanical stress and the presence of stricturing disease, and surgical complications play a role. Perianal penetrating disease represents a more severe phenotype in IBD. Pouch-associated fistula can arise as a result of an anastomotic leak, surgical complications, or Crohn's disease (CD) of the pouch. Classification is site-dependent, includes a range of severity, and informs management. It is important to determine associated symptoms and recognize the complex interplay of underlying etiologies to form the basis of appropriate care.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Inflammatory Bowel Diseases
/
Colitis, Ulcerative
/
Crohn Disease
/
Fistula
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Gastrointest Endosc Clin N Am
Journal subject:
DIAGNOSTICO POR IMAGEM
/
GASTROENTEROLOGIA
/
TERAPEUTICA
Year:
2022
Document type:
Article
Affiliation country:
Estados Unidos