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Mannobioside biomimetics that trigger DC-SIGN binding selectivity.
Herrera-González, Irene; Thépaut, Michel; Sánchez-Fernández, Elena M; di Maio, Antonio; Vivès, Corinne; Rojo, Javier; García Fernández, José M; Fieschi, Franck; Nieto, Pedro M; Ortiz Mellet, Carmen.
Affiliation
  • Herrera-González I; Department of Organic Chemistry, Faculty of Chemistry, University of Seville, C/Profesor García González 1, Seville 41012, Spain. mellet@us.es.
  • Thépaut M; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, Grenoble 38044, France. franck.fieschi@ibs.fr.
  • Sánchez-Fernández EM; Department of Organic Chemistry, Faculty of Chemistry, University of Seville, C/Profesor García González 1, Seville 41012, Spain. mellet@us.es.
  • di Maio A; Instituto de Investigaciones Químicas (IIQ), CSIC - Universidad de Sevilla, Américo Vespucio 49, Sevilla 41092, Spain. Pedro.nieto@iiq.csic.es.
  • Vivès C; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, Grenoble 38044, France. franck.fieschi@ibs.fr.
  • Rojo J; Instituto de Investigaciones Químicas (IIQ), CSIC - Universidad de Sevilla, Américo Vespucio 49, Sevilla 41092, Spain. Pedro.nieto@iiq.csic.es.
  • García Fernández JM; Instituto de Investigaciones Químicas (IIQ), CSIC - Universidad de Sevilla, Américo Vespucio 49, Sevilla 41092, Spain. Pedro.nieto@iiq.csic.es.
  • Fieschi F; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, Grenoble 38044, France. franck.fieschi@ibs.fr.
  • Nieto PM; Instituto de Investigaciones Químicas (IIQ), CSIC - Universidad de Sevilla, Américo Vespucio 49, Sevilla 41092, Spain. Pedro.nieto@iiq.csic.es.
  • Ortiz Mellet C; Department of Organic Chemistry, Faculty of Chemistry, University of Seville, C/Profesor García González 1, Seville 41012, Spain. mellet@us.es.
Chem Commun (Camb) ; 58(86): 12086-12089, 2022 Oct 27.
Article in En | MEDLINE | ID: mdl-36219150
Selective DC-SIGN targeting vs. langerin might lead to anti-infective agents, given their counteracting effects upon infection by some pathogens. Here we show that multivalent sp2-iminosugar-containing mannobioside analogs can achieve total DC-SIGN selectivity by levering the canonic binding mode towards high-mannose oligosaccharide ligands, behaving as factual biomimics.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mannose-Binding Lectins / Biomimetics Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: España Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mannose-Binding Lectins / Biomimetics Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: España Country of publication: Reino Unido