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Natural carbazole alkaloid murrayafoline A displays potent anti-neuroinflammatory effect by directly targeting transcription factor Sp1 in LPS-induced microglial cells.
Li, Chao-Hua; Zhou, Ying; Tu, Peng-Fei; Zeng, Ke-Wu; Jiang, Yong.
Affiliation
  • Li CH; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • Zhou Y; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • Tu PF; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • Zeng KW; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address: ZKW@bjmu.edu.cn.
  • Jiang Y; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address: yongjiang@bjmu.edu.cn.
Bioorg Chem ; 129: 106178, 2022 12.
Article in En | MEDLINE | ID: mdl-36220002
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbazoles / Sp1 Transcription Factor / Murraya / Alkaloids / Neuroinflammatory Diseases / Anti-Inflammatory Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Bioorg Chem Year: 2022 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbazoles / Sp1 Transcription Factor / Murraya / Alkaloids / Neuroinflammatory Diseases / Anti-Inflammatory Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Bioorg Chem Year: 2022 Document type: Article Affiliation country: China