Research on the influence of APOBEC family on the occurrence, diagnosis, and treatment of various tumors.
J Cancer Res Clin Oncol
; 149(1): 357-366, 2023 Jan.
Article
in En
| MEDLINE
| ID: mdl-36222899
ABSTRACT
BACKGROUND:
Apolipoprotein B mRNA-editing catalytic polypeptide (APOBEC) is a family of highly efficient cytidine deaminase enzymes. APOBECs have been proven to deaminate cytidine on single-stranded DNA or RNA. Inducing the deamination of cytosine on the target gene into uracil, which exerts a variety of physiological functions, plays an important role in innate immunity, adaptive immunity, and antiviral. As the research progresses, APOBECs have been confirmed to be highly expressed in a variety of tumors, causing abnormal mutations in host genes, leading to inactivation of tumor suppressor genes or activation of proto-oncogenes, and their role in tumor development and as diagnostic and treatment markers gradually be found.CONCLUSION:
This article will review the mechanism of APOBECs and their impact on tumor occurrence, development, diagnosis, and treatment, and provide a theoretical basis for future tumor treatment.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neoplasms
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
J Cancer Res Clin Oncol
Year:
2023
Document type:
Article
Affiliation country:
China