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Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential Oral On-Demand Treatment for Hereditary Angioedema.
Davie, Rebecca L; Edwards, Hannah J; Evans, D Michael; Hodgson, Simon T; Stocks, Michael J; Smith, Alun J; Rushbrooke, Louise J; Pethen, Stephen J; Roe, Michael B; Clark, David E; McEwan, Paul A; Hampton, Sally L.
Affiliation
  • Davie RL; KalVista Pharmaceuticals Limited, Porton Science Park, Salisbury, SP4 0BF, U.K.
  • Edwards HJ; KalVista Pharmaceuticals Limited, Porton Science Park, Salisbury, SP4 0BF, U.K.
  • Evans DM; KalVista Pharmaceuticals Limited, Porton Science Park, Salisbury, SP4 0BF, U.K.
  • Hodgson ST; KalVista Pharmaceuticals Limited, Porton Science Park, Salisbury, SP4 0BF, U.K.
  • Stocks MJ; School of Pharmacy, University of Nottingham, University Park Campus, Nottingham NG7 2RD, U.K.
  • Smith AJ; Sygnature Discovery, Biocity, Pennyfoot Street, Nottingham, NG1 1GR, U.K.
  • Rushbrooke LJ; KalVista Pharmaceuticals Limited, Porton Science Park, Salisbury, SP4 0BF, U.K.
  • Pethen SJ; KalVista Pharmaceuticals Limited, Porton Science Park, Salisbury, SP4 0BF, U.K.
  • Roe MB; KalVista Pharmaceuticals Limited, Porton Science Park, Salisbury, SP4 0BF, U.K.
  • Clark DE; Charles River Early Discovery, 6-9 Spire Green Centre, Harlow, Essex CM19 5TR, U.K.
  • McEwan PA; Evotec, 114 Innovation Drive Milton Science Park, Abingdon, OX14 4RZ, U.K.
  • Hampton SL; KalVista Pharmaceuticals Limited, Porton Science Park, Salisbury, SP4 0BF, U.K.
J Med Chem ; 65(20): 13629-13644, 2022 10 27.
Article in En | MEDLINE | ID: mdl-36251573
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Angioedemas, Hereditary Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Angioedemas, Hereditary Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Reino Unido