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Effect of temperature and propylene glycol as a cosolvent on dissolution of clotrimazole.
Nemati, A; Rezaei, H; Poturcu, K; Hanaee, J; Jouyban, A; Zhao, H; Rahimpour, E.
Affiliation
  • Nemati A; Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Rezaei H; Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Poturcu K; Department of Chemistry, Arts and Science Faculty, Suleyman Demirel University, Isparta, Turkey.
  • Hanaee J; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Jouyban A; Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Faculty of Pharmacy, Near East University, PO BOX: 99138 Nicosia, North Cyprus, Mersin 10, Turkey.
  • Zhao H; College of Chemistry & Chemical Engineering, YangZhou University, YangZhou, 225002 Jiangsu, PR China.
  • Rahimpour E; Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, 5165665811 Tabriz, Iran. Electronic address: rahimpour_e@yahoo.com.
Ann Pharm Fr ; 81(2): 258-266, 2023 Mar.
Article in En | MEDLINE | ID: mdl-36252866
ABSTRACT
Herein, the solubility study of clotrimazole was performed in a propylene glycol+water system. The solubility values were fitted to various cosolvency equations. The model accuracies were studied with the computation of the mean relative deviations. The thermodynamic behavior was investigated according to the van't Hoff and Gibbs equations for clotrimazole in the propylene glycol+water system. Furthermore, the density data for clotrimazole were determined in mixtures of propylene glycol+water and fitted to the Jouyban-Acree equation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Clotrimazole / Propylene Glycol Language: En Journal: Ann Pharm Fr Year: 2023 Document type: Article Affiliation country: Irán
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Clotrimazole / Propylene Glycol Language: En Journal: Ann Pharm Fr Year: 2023 Document type: Article Affiliation country: Irán