Evaluation of peripheral nerve regeneration in Murphy Roths Large mouse strain following transection injury.
Regen Med
; 18(1): 37-53, 2023 01.
Article
in En
| MEDLINE
| ID: mdl-36255077
ABSTRACT
Aim:
Murphy Roths Large (MRL/MpJ) mice have demonstrated the ability to heal with minimal or no scar formation in several tissue types. In order to identify a novel animal model, this study sought to evaluate whether this attribute applies to peripheral nerve regeneration. Materials &methods:
This was a two-phase study. 6-week-old male mice were divided into two interventional groups nerve repair and nerve graft. The MRL/MpJ was compared with the C57BL/6J strain for evaluation of both functional and histological outcomes.Results:
MRL/MpJ strain demonstrated superior axon myelination and less scar formation, however functional outcomes did not show significant difference between strains.Conclusion:
Superior histological outcomes did not translate into superior peripheral nerve regeneration in MRL/MpJ strain.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nerve Regeneration
Limits:
Animals
Language:
En
Journal:
Regen Med
Year:
2023
Document type:
Article
Affiliation country:
Estados Unidos