Assessment of Anastomotic Viability With Spectroscopic Real-time Oxygen Saturation Measurement in a Porcine Study.
Surg Innov
; 30(3): 349-355, 2023 Jun.
Article
in En
| MEDLINE
| ID: mdl-36255230
ABSTRACT
OBJECTIVE:
Anastomotic leakage (AL) is a severe complication following intestinal procedures. Intra.Ox™ by ViOptix Inc (Newark, CA, USA) is a novel, FDA-approved spectroscopic device which enables real-time measurement of mixed tissue oxygen saturation (StO2). Using a porcine model, this study explores the correlation between StO2 measurements and AL formation as well as investigates the applicability of Intra.Ox™ in the clinical setting.METHODS:
Eleven female swine were divided into 3 groups to explore AL formation in different ischemic conditions. Group 1 100% mesenteric-vascular ligation, n = 3; Group 2 50% ligation, n = 5; Group 3 No mesenteric ligation, n = 3. StO2 at the anastomotic line was measured before and after vessel ligation and anastomosis. Measurements were taken at 6 distinct locations along afferent and efferent loops. AL was evaluated on postoperative day 5 by re-laparotomy.RESULTS:
AL rate was 100%, 60% and 0% in groups 1, 2 and 3, respectively. Post-anastomotic StO2 in group 1 (22.9 ± 18.5%) and 2 (39.2 ± 20.1%) were significantly lower than in group 3 (53.1 ± 8.3%, p<.0001). Post-anastomotic StO2 readings ≤40% indicated AL potential with 100% sensitivity,+ 80% specificity, positive predictive value of 85.7% and negative predictive value of 100%.CONCLUSION:
This study demonstrates the value of Intra.Ox™ in assessing local perfusion and indicate the association between low StO2 and AL by providing accurate, real-time, noninvasive tissue oxygenation measurements at anastomotic sites. Further studies are required to investigate the clinical application of this novel device in intestinal surgery.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anastomotic Leak
/
Oxygen Saturation
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Surg Innov
Year:
2023
Document type:
Article
Affiliation country:
Estados Unidos