Maternal hemoglobin levels and neonatal outcomes: the Japan Environment and Children's Study.
J Matern Fetal Neonatal Med
; 35(26): 10472-10480, 2022 Dec.
Article
in En
| MEDLINE
| ID: mdl-36273853
ABSTRACT
BACKGROUND:
Low birth weight (LBW), small for gestational age (SGA), and preterm birth (PTB) are important neonatal outcomes that may affect infant morbidity and mortality. The aim of this study is to investigate associations between maternal hemoglobin (Hb) concentrations and pregnancy outcomes of LBW, SGA, and PTB.METHODS:
This was a prospective birth cohort study using data of the Japan Environment and Children's Study. Participants were divided into five groups according to maternal Hb (g/dL) in the first and second trimesters group 1, Hb < 9; group 2, 9 ≤ Hb < 11.0; group 3, 11.0 ≤ Hb < 13.0; group 4, 13.0 < Hb < 14.0; and group 5, 14.0 ≤ Hb. We examined the relationships between LBW, PTB, SGA, and maternal Hb in the first and second trimesters.RESULTS:
Excluding 29,673, a total of 74,392 newborns (first trimester n = 39,084, second trimester n = 35,308) were included. We obtained adjusted odds ratios (aORs) (95% confidence intervals (CIs)) using multivariate analysis; compared with group 3 in the first trimesters, women in group 1 were at increased risk of PTB (aOR, 3.20; 95% CI, 1.69-6.09), LBW (aOR, 2.21; 95% CI, 1.19-4.09). In the second trimester, multivariate analysis revealed that, compared with group 3 in the second trimester, women in group 1 were at increased risk of PTB (aOR, 2.30; 95% CI, 1.19-4.42) and women in group 5 were at increased risk of LBW (aOR, 1.87; 95% CI, 1.24-2.81) and PTB (aOR, 1.73; 95% CI, 1.06-2.83).CONCLUSIONS:
Elevated maternal Hb in the second trimester was associated with risks of PTB and LBW.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Infant, Small for Gestational Age
/
Premature Birth
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Child
/
Female
/
Humans
/
Newborn
/
Pregnancy
Country/Region as subject:
Asia
Language:
En
Journal:
J Matern Fetal Neonatal Med
Journal subject:
OBSTETRICIA
/
PERINATOLOGIA
Year:
2022
Document type:
Article
Affiliation country:
Japón