Association between rs1799971 in the mu opioid receptor gene and methadone maintenance treatment response.
J Clin Lab Anal
; 36(11): e24750, 2022 Nov.
Article
in En
| MEDLINE
| ID: mdl-36305091
ABSTRACT
OBJECTIVE:
Genetic variations can affect individual response to methadone maintenance treatment (MMT) for heroin addiction. The A118G variant (rs1799971) in the mu opioid receptor gene (OPRM1) is a potential candidate single nucleotide polymorphism (SNP) for personalized MMT. This study determined whether rs1799971 is related to MMT response or dose.METHODS:
We recruited 286 MMT patients from a Han Chinese population. The rs1799971 genotype was determined via TaqMan genotyping assay. The genetic effect of this SNP on MMT response or dose was evaluated using logistic regression. A meta-analysis was performed to merge all available data to evaluate the role of rs1799971 in MMT using RevMan 5.3 software.RESULTS:
No statistical significance was observed in the association between the OPRM1 rs1799971 and MMT response or dose in our Chinese cohort. Meta-analysis indicated that the OPRM1 A118G variation was not significantly associated with MMT response or dose requirement.CONCLUSION:
The results suggest that rs1799971 in OPRM1 might not play a critical role alone in influencing MMT response or dose.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Heroin Dependence
/
Methadone
Type of study:
Risk_factors_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
J Clin Lab Anal
Journal subject:
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Year:
2022
Document type:
Article
Affiliation country:
China