Laying the foundation for enhancing safety of desmopressin in older people: Validation of capillary blood sodium levels.
Neurourol Urodyn
; 42(1): 303-308, 2023 01.
Article
in En
| MEDLINE
| ID: mdl-36321798
ABSTRACT
PURPOSE:
We aim to make desmopressin a safe treatment option for (older) patients at risk for hyponatremia, by introducing a new way of sodium monitoring. The goal is to reduce the risk of hyponatremia, enhance patient safety and ultimately introduce self-monitoring of sodium levels. The first step in the aforementioned is to validate capillary sodium. MATERIALS ANDMETHODS:
100 randomly selected patients admitted to the urology department received a single finger prick to collect capillary blood (250 µl) in a lithium-heparin tube. Each patient acted as its own control for the capillary and venous blood sample. Venous and capillary plasma sodium were analyzed by indirect ion-selective electrode measurement. The primary outcome was the agreement between capillary and venous sodium measurements, measured by the intra-class correlation coefficient (ICC).RESULTS:
One hundred paired blood samples were obtained of which four were excluded. There was no significant statistical difference observed between venous and capillary sodium (-0.23 mmol/L, p = 0.374). The ICC for single measures between capillary and venous sodium was 0.82 (95% confidence interval 0.75-0.88). Inter-method differences analyzed by a Bland-Altman plot and a Passing-Bablock regression did not reveal a statistically significant difference between both groups.CONCLUSIONS:
We demonstrated that venous and capillary sodium levels are interchangeable, taken into account the inter- and intravariability between analyses. We provided the first step towards a simple and safe solution for frequent sodium monitoring through a minimal invasive capillary blood collection. The results are of direct clinical relevance to safely use desmopressin in (older) patients at risk.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hyponatremia
Limits:
Humans
Language:
En
Journal:
Neurourol Urodyn
Year:
2023
Document type:
Article
Affiliation country:
Bélgica