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S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters.
Sasaki, Michihito; Tabata, Koshiro; Kishimoto, Mai; Itakura, Yukari; Kobayashi, Hiroko; Ariizumi, Takuma; Uemura, Kentaro; Toba, Shinsuke; Kusakabe, Shinji; Maruyama, Yuki; Iida, Shun; Nakajima, Noriko; Suzuki, Tadaki; Yoshida, Shinpei; Nobori, Haruaki; Sanaki, Takao; Kato, Teruhisa; Shishido, Takao; Hall, William W; Orba, Yasuko; Sato, Akihiko; Sawa, Hirofumi.
Affiliation
  • Sasaki M; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan.
  • Tabata K; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan.
  • Kishimoto M; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan.
  • Itakura Y; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan.
  • Kobayashi H; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan.
  • Ariizumi T; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan.
  • Uemura K; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan.
  • Toba S; Shionogi & Co. Ltd., Osaka 561-0825, Japan.
  • Kusakabe S; Laboratory of Biomolecular Science, Faculty of Pharmaceutical Science, Hokkaido University, Sapporo 060-0812, Japan.
  • Maruyama Y; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan.
  • Iida S; Shionogi & Co. Ltd., Osaka 561-0825, Japan.
  • Nakajima N; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan.
  • Suzuki T; Shionogi & Co. Ltd., Osaka 561-0825, Japan.
  • Yoshida S; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan.
  • Nobori H; Shionogi & Co. Ltd., Osaka 561-0825, Japan.
  • Sanaki T; Department of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
  • Kato T; Department of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
  • Shishido T; Department of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
  • Hall WW; Shionogi & Co. Ltd., Osaka 561-0825, Japan.
  • Orba Y; Shionogi & Co. Ltd., Osaka 561-0825, Japan.
  • Sato A; Shionogi & Co. Ltd., Osaka 561-0825, Japan.
  • Sawa H; Shionogi & Co. Ltd., Osaka 561-0825, Japan.
Sci Transl Med ; 15(679): eabq4064, 2023 01 18.
Article in En | MEDLINE | ID: mdl-36327352
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2023 Document type: Article Affiliation country: Japón
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2023 Document type: Article Affiliation country: Japón