The ocular graft-versus-host disease: the path from current knowledge to future managements.
Eye (Lond)
; 37(10): 1982-1992, 2023 07.
Article
in En
| MEDLINE
| ID: mdl-36333534
ABSTRACT
BACKGROUND:
Graft-versus-host disease (GVHD) is one of the major complications of allogenic haematopoietic stem cell transplantation (HSCT). The manifestation of ocular GVHD (oGVHD) is variable and may involve cornea, lacrimal gland, conjunctiva, eyelid, and/or nasolacrimal duct. We reviewed and summarized the current managements of oGVHD with specific focus on the emerging therapeutic advances.METHODS:
PubMed, Web of Science, and Google Scholar were searched for relevant literatures published within 20 years. Keywords used included "Graft-Versus-Host Disease", "GVHD", "ocular", "ocular surface", "ocular GVHD", "oGVHD", "dry eye", "keratitis", etc.RESULTS:
Current managements of oGVHD can be classified into topical immunosuppressants, local tear-preservatory treatments, local non-pharmacological/surgical interventions, and systemic treatments. Additionally, some innovative therapies with promising treatment effects have been proposed, including topical target therapies, epitheliotrophic and neurotrophic treatments, recombinant DNase eye drops, mesenchymal stromal cell injection, and more.CONCLUSIONS:
Clinical managements of oGVHD are administered in a symptom-based, stepwise manner. The advances in innovative therapies may help improve clinical outcomes, and it is essential that physicians stay updated with these novel treatment options.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dry Eye Syndromes
/
Hematopoietic Stem Cell Transplantation
/
Graft vs Host Disease
Limits:
Humans
Language:
En
Journal:
Eye (Lond)
Journal subject:
OFTALMOLOGIA
Year:
2023
Document type:
Article
Affiliation country:
Taiwán