Paraoxonase 1 and atrial fibrillation: Is there a relationship?
Medicine (Baltimore)
; 101(46): e31553, 2022 Nov 18.
Article
in En
| MEDLINE
| ID: mdl-36401436
ABSTRACT
Atrial fibrillation (AF) is associated with oxidative stress and inflammation. Paraoxonase-1 (PON1), circulates in blood bound to high-density lipoproteins and reduces systemic oxidative stress. The aim of this study was to evaluate PON1 serum concentration and PON1 arylesterase activity (AREase) in patients with AF. We studied a group of 67 patients with symptomatic paroxysmal or persistent AF admitted for cardioversion and a control group of 59 patients without AF. Clinical parameters, lipid profile, PON1 concentration and AREase were evaluated. A significant difference in serum PON1 concentration and in AREase was found among the two groups. In a multivariate linear regression model, the presence of AF was associated with low PON1 concentration (Pâ
=â
.022). The body mass index was also independently associated with PON1 values (Pâ
<â
.001). Only the high-density lipoproteins-cholesterol level was independently associated with AREase (Pâ
=â
.002). PON1 serum concentrations and AREase were diminished in patients with AF, and the presence of AF was independently associated with low PON1 values.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Atrial Fibrillation
/
Aryldialkylphosphatase
Limits:
Humans
Language:
En
Journal:
Medicine (Baltimore)
Year:
2022
Document type:
Article
Affiliation country:
Rumanía