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BRAF activation by metabolic stress promotes glycolysis sensitizing NRASQ61-mutated melanomas to targeted therapy.
McGrail, Kimberley; Granado-Martínez, Paula; Esteve-Puig, Rosaura; García-Ortega, Sara; Ding, Yuxin; Sánchez-Redondo, Sara; Ferrer, Berta; Hernandez-Losa, Javier; Canals, Francesc; Manzano, Anna; Navarro-Sabaté, Aura; Bartrons, Ramón; Yanes, Oscar; Pérez-Alea, Mileidys; Muñoz-Couselo, Eva; Garcia-Patos, Vicenç; Recio, Juan A.
Affiliation
  • McGrail K; Biomedical Research in Melanoma-Animal Models and Cancer Laboratory, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron Hospital Barcelona-UAB, Barcelona, 08035, Spain.
  • Granado-Martínez P; Biomedical Research in Melanoma-Animal Models and Cancer Laboratory, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron Hospital Barcelona-UAB, Barcelona, 08035, Spain.
  • Esteve-Puig R; Biomedical Research in Melanoma-Animal Models and Cancer Laboratory, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron Hospital Barcelona-UAB, Barcelona, 08035, Spain.
  • García-Ortega S; MAJ3 Capital S.L, Barcelona, 08018, Spain.
  • Ding Y; Biomedical Research in Melanoma-Animal Models and Cancer Laboratory, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron Hospital Barcelona-UAB, Barcelona, 08035, Spain.
  • Sánchez-Redondo S; Biomedical Research in Melanoma-Animal Models and Cancer Laboratory, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron Hospital Barcelona-UAB, Barcelona, 08035, Spain.
  • Ferrer B; Biomedical Research in Melanoma-Animal Models and Cancer Laboratory, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron Hospital Barcelona-UAB, Barcelona, 08035, Spain.
  • Hernandez-Losa J; Microenvironment & Metastasis Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
  • Canals F; Biomedical Research in Melanoma-Animal Models and Cancer Laboratory, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron Hospital Barcelona-UAB, Barcelona, 08035, Spain.
  • Manzano A; Anatomy Pathology Department, Vall d'Hebron Hospital Barcelona-UAB, Barcelona, 08035, Spain.
  • Navarro-Sabaté A; Anatomy Pathology Department, Vall d'Hebron Hospital Barcelona-UAB, Barcelona, 08035, Spain.
  • Bartrons R; Proteomics Laboratory, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, 08035, Spain.
  • Yanes O; Department of Physiological Sciences, University of Barcelona, Bellvitge Biomedical Research Institute, Barcelona, Spain.
  • Pérez-Alea M; Department of Physiological Sciences, University of Barcelona, Bellvitge Biomedical Research Institute, Barcelona, Spain.
  • Muñoz-Couselo E; Department of Physiological Sciences, University of Barcelona, Bellvitge Biomedical Research Institute, Barcelona, Spain.
  • Garcia-Patos V; Universitat Rovira i Virgili, Department of Electronic Engineering, IISPV, Tarragona, Spain.
  • Recio JA; CIBER on Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain.
Nat Commun ; 13(1): 7113, 2022 11 19.
Article in En | MEDLINE | ID: mdl-36402789
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins B-raf / Melanoma Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Document type: Article Affiliation country: España Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins B-raf / Melanoma Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Document type: Article Affiliation country: España Country of publication: Reino Unido