Comparing the efficacy of different methods of faecal microbiota transplantation via oral capsule, oesophagogastroduodenoscopy, colonoscopy, or gastric tube.
J Hosp Infect
; 131: 234-243, 2023 Jan.
Article
in En
| MEDLINE
| ID: mdl-36414164
ABSTRACT
BACKGROUND:
The increasing prevalence of multidrug-resistant organism (MDRO) carriage poses major challenges to medicine as healthcare costs increase. Recently, faecal microbiota transplantation (FMT) has been discussed as a novel and effective method for decolonizing MDRO.AIM:
To compare the efficacy of different FMT methods to optimize the success rate of decolonization in patients with MDRO carriage.METHODS:
This prospective cohort study enrolled patients with MDRO carriages from 2018 to 2021. Patients underwent FMT via one of the followingmethods:
oral capsule, oesophagogastroduodenoscopy (EGD), colonoscopy, or gastric tube.FINDINGS:
A total of 57 patients underwent FMT for MDRO decolonization. The colonoscopy group required the shortest time for decolonization, whereas the EGD group required the longest (24.9 vs 190.4 days, P = 0.022). The decolonization rate in the oral capsule group was comparable to that in the EGD group (84.6% vs 85.7%, P = 0.730). An important clinical factor associated with decolonization failure was antibiotic use after FMT (odds ratio = 6.810, P = 0.008). All four groups showed reduced proportions of MDRO species in microbiome analysis after FMT.CONCLUSION:
Compared to other conventional methods, the oral capsule is an effective FMT method for patients who can tolerate an oral diet. The discontinuation of antibiotics after FMT is a key factor in the success of decolonization.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fecal Microbiota Transplantation
/
Anti-Bacterial Agents
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
J Hosp Infect
Year:
2023
Document type:
Article
Affiliation country:
Corea del Sur