Your browser doesn't support javascript.
loading
Management of type 1 immediate hypersensitivity reactions to antituberculosis drug: succesful desensitization.
Katran, Zeynep Yegin; Bulut, Ismet; Babalik, Aylin; Keren, Metin.
Affiliation
  • Katran ZY; Department of Allergy and Immunology, University of Health Sciences, Süreyyapasa Training and Research Hospital, Istanbul, Turkey. zynpyegin@hotmail.com.
  • Bulut I; Department of Allergy and Immunology, University of Health Sciences, Süreyyapasa Training and Research Hospital, Istanbul, Turkey.
  • Babalik A; Department of Chest Diseases, University of Health Sciences, Süreyyapasa Training and Research Hospital, Istanbul, Turkey.
  • Keren M; Department of Allergy and Immunology, University of Health Sciences, Süreyyapasa Training and Research Hospital, Istanbul, Turkey.
Allergy Asthma Clin Immunol ; 18(1): 97, 2022 Nov 21.
Article in En | MEDLINE | ID: mdl-36414980
ABSTRACT

OBJECTIVE:

In this study, it was aimed to investigate the prevalence of type 1 hypersensitivity reaction under tuberculosis treatment and the management of hypersensitivity.

METHODS:

The study is a case series. All of the patients who were hospitalized between 01.02.2015-01.05.2021 were examined. All patients who developed a drug-induced type 1 immediate hypersensitivity reaction were included. Antituberculosis drugs were given with the protocol made by Buhari et al. However, unlike what is stated in the protocol, pyrazinamide was given last during the administration of the drugs.

RESULTS:

2677 patients received inpatient tuberculosis treatment; type 1 immediate hypersensitivity reactions were seen in 94 (3.5%) patients. Due to missing data in the file, 81 patients were included in the study. 44 (54.3%) of the cases were women; mean age (mean ± SD) 50.7 ± 17.69 years; 76 (93.8%) of them are citizens of the Republic of Turkey; 58 (71.6%) of them were diagnosed bacteriologically; 65 (80.2%) of them were pulmonary tuberculosis. The most common skin finding was urticaria in 49 (60.5%). The drug responsible for the most common reaction was pyrazinamide. In 49 (60.5%) cases, drugs were given by desensitization and it was successful. The duration of treatment was 7.91 ± 2.5 months (6-18 months). When evaluated in terms of treatment results, 68 (84%) patients successfully completed the treatment.

CONCLUSION:

Our study is the largest series of patients who developed type 1 immediate hypersensitivity reaction while receiving antituberculosis treatment. A practical, easy desensitization scheme has been shared.

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Guideline / Risk_factors_studies Language: En Journal: Allergy Asthma Clin Immunol Year: 2022 Document type: Article Affiliation country: Turquía

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Guideline / Risk_factors_studies Language: En Journal: Allergy Asthma Clin Immunol Year: 2022 Document type: Article Affiliation country: Turquía
...