[Real-world evidence and randomized controlled trials: the initiation, implementation, progress interpretation and revelation of RCT DUPLICATE (part 1)].
Zhonghua Liu Xing Bing Xue Za Zhi
; 43(11): 1828-1834, 2022 Nov 10.
Article
in Zh
| MEDLINE
| ID: mdl-36444469
ABSTRACT
In recent years, researchers, pharmaceutical companies, and political makers gradually using more real-world data (RWD) to produce real-world evidence (RWE) for policy-making. A research team of Harvard University launched the RCT DUPLICATE project in 2018, aiming to replicate 30 randomized controlled trials using the medical claims database in order to explore methods for quantifying the efficacy-effectiveness gap and explain its potential sources, to enhance the credibility of the RWE. This paper reviews the background of RCT DUPLICATE Initiative, highlights the research purposes, research design and implementation process of the RCT DUPLICATE Initiative, to help domestic scholars better understand the scope and application value of RWE.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Research Personnel
/
Cognition
Type of study:
Clinical_trials
Limits:
Humans
Language:
Zh
Journal:
Zhonghua Liu Xing Bing Xue Za Zhi
Year:
2022
Document type:
Article
Affiliation country:
China