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Synthesis of an amphiphilic vancomycin aglycone derivative inspired by polymyxins: overcoming glycopeptide resistance in Gram-positive and Gram-negative bacteria in synergy with teicoplanin in vitro.
Szucs, Zsolt; Bereczki, Ilona; Fenyvesi, Ferenc; Herczegh, Pál; Ostorházi, Eszter; Borbás, Anikó.
Affiliation
  • Szucs Z; Department of Pharmaceutical Chemistry, University of Debrecen, Egyetem Tér 1, 4032, Debrecen, Hungary.
  • Bereczki I; Department of Pharmaceutical Chemistry, University of Debrecen, Egyetem Tér 1, 4032, Debrecen, Hungary.
  • Fenyvesi F; Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, 4032, Debrecen, Hungary.
  • Herczegh P; Department of Pharmaceutical Chemistry, University of Debrecen, Egyetem Tér 1, 4032, Debrecen, Hungary.
  • Ostorházi E; Department of Medical Microbiology, Semmelweis University, Nagyvárad Tér 4, 1089, Budapest, Hungary. ostorhazi.eszter@med.semmelweis-univ.hu.
  • Borbás A; Department of Pharmaceutical Chemistry, University of Debrecen, Egyetem Tér 1, 4032, Debrecen, Hungary. borbas.aniko@pharm.unideb.hu.
Sci Rep ; 12(1): 20921, 2022 12 03.
Article in En | MEDLINE | ID: mdl-36463278
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Teicoplanin / Polymyxins / Drug Resistance, Bacterial Language: En Journal: Sci Rep Year: 2022 Document type: Article Affiliation country: Hungria Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Teicoplanin / Polymyxins / Drug Resistance, Bacterial Language: En Journal: Sci Rep Year: 2022 Document type: Article Affiliation country: Hungria Country of publication: Reino Unido