Exploring the causality between ankylosing spondylitis and atrial fibrillation: A two-sample Mendelian randomization study.
Front Genet
; 13: 951893, 2022.
Article
in En
| MEDLINE
| ID: mdl-36468019
ABSTRACT
Objective:
To study whether ankylosing spondylitis (AS) has a causal effect on the risk of atrial fibrillation (AF) using two-sample Mendelian randomization (MR) analysis.Methods:
Single nucleotide polymorphisms (SNPs) were selected as independent instrumental variables (IVs) from a GWAS study of AS. Summary data from a large-scale GWAS meta-analysis of AF was utilized as the outcome dataset. Inverse-variance weighted (IVW) model was used for the primary analysis. Multiple sensitivity and heterogeneity tests were conducted to confirm the robustness of the results.Results:
In total, 18 SNPs were identified as IVs for MR analysis. Five MR methods consistently found that ankylosing spondylitis was not causally associated with atrial fibrillation (IVW OR = 0.983 (0.894, 1.080), p = 0.718; MR-Egger OR = 1.190 (0.973, 1.456), p = 0.109; Simple mode OR = 0.888 (0.718, 1.098), p = 0.287; Weighted mode OR = 0.989 (0.854, 1.147), p = 0.890; Weight median OR = 0.963 (0.852, 1.088), p = 0.545). Leave-one-out analysis supported the stability of MR results. Both the MR-Egger intercept and MR-PRESSO method revealed the absence of horizontal pleiotropy.Conclusion:
The two-sample MR analysis did not support a causal relationship between AS and the risk of AF.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Clinical_trials
/
Etiology_studies
/
Prognostic_studies
Language:
En
Journal:
Front Genet
Year:
2022
Document type:
Article
Affiliation country:
China