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Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors.
Gao, Shenghua; Song, Letian; Claff, Tobias; Woodson, Molly; Sylvester, Katharina; Jing, Lanlan; Weiße, Renato H; Cheng, Yusen; Sträter, Norbert; Schäkel, Laura; Gütschow, Michael; Ye, Bing; Yang, Mianling; Zhang, Tao; Kang, Dongwei; Toth, Karoly; Tavis, John; Tollefson, Ann E; Müller, Christa E; Zhan, Peng; Liu, Xinyong.
Affiliation
  • Gao S; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan250012, China.
  • Song L; Shenzhen Research Institute of Shandong University, A301 Virtual University Park in South District, Shenzhen518057, Guangdong, China.
  • Claff T; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan250012, China.
  • Woodson M; PharmaCenter Bonn & Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn53113, Germany.
  • Sylvester K; Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri63104, United States.
  • Jing L; Saint Louis University Institute for Drug and Biotherapeutic Innovation, St. Louis, Missouri63104, United States.
  • Weiße RH; PharmaCenter Bonn & Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn53113, Germany.
  • Cheng Y; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan250012, China.
  • Sträter N; Institute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, Leipzig University, Deutscher Platz 5, Leipzig04103, Germany.
  • Schäkel L; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan250012, China.
  • Gütschow M; Institute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, Leipzig University, Deutscher Platz 5, Leipzig04103, Germany.
  • Ye B; PharmaCenter Bonn & Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn53113, Germany.
  • Yang M; PharmaCenter Bonn & Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn53113, Germany.
  • Zhang T; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan250012, China.
  • Kang D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan250012, China.
  • Toth K; Shandong Qidu Pharmaceutical Research Institute, Yinfeng Biological City, Chunlan Road 1177, High Tech District, Ji'nan250101, China.
  • Tavis J; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan250012, China.
  • Tollefson AE; Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri63104, United States.
  • Müller CE; Saint Louis University Institute for Drug and Biotherapeutic Innovation, St. Louis, Missouri63104, United States.
  • Zhan P; Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri63104, United States.
  • Liu X; Saint Louis University Institute for Drug and Biotherapeutic Innovation, St. Louis, Missouri63104, United States.
J Med Chem ; 65(24): 16902-16917, 2022 12 22.
Article in En | MEDLINE | ID: mdl-36475694
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: China Country of publication: Estados Unidos
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: China Country of publication: Estados Unidos