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Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors.
Arnold, Moriah R; Langelier, Marie-France; Gartrell, Jessica; Kirby, Ilsa T; Sanderson, Daniel J; Bejan, Daniel S; Sileikyte, Justina; Sundalam, Sunil K; Nagarajan, Shanthi; Marimuthu, Parthiban; Duell, Anna K; Shelat, Anang A; Pascal, John M; Cohen, Michael S.
Affiliation
  • Arnold MR; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Pk. Rd., Portland, OR 97210, USA.
  • Langelier MF; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada.
  • Gartrell J; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Kirby IT; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Pk. Rd., Portland, OR 97210, USA.
  • Sanderson DJ; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Pk. Rd., Portland, OR 97210, USA.
  • Bejan DS; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Pk. Rd., Portland, OR 97210, USA.
  • Sileikyte J; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Pk. Rd., Portland, OR 97210, USA.
  • Sundalam SK; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Pk. Rd., Portland, OR 97210, USA.
  • Nagarajan S; Medicinal Chemistry Core, Oregon Health & Science University, Portland, OR 97210, USA.
  • Marimuthu P; Structural Bioinformatics Laboratory, Åbo Akademi University, Faculty of Science and Engineering, 20520 Turku, Finland.
  • Duell AK; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Pk. Rd., Portland, OR 97210, USA.
  • Shelat AA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Pascal JM; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada.
  • Cohen MS; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Pk. Rd., Portland, OR 97210, USA. Electronic address: cohenmic@ohsu.edu.
Cell Chem Biol ; 29(12): 1694-1708.e10, 2022 12 15.
Article in En | MEDLINE | ID: mdl-36493759
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Poly(ADP-ribose) Polymerase Inhibitors / Antineoplastic Agents Language: En Journal: Cell Chem Biol Year: 2022 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Poly(ADP-ribose) Polymerase Inhibitors / Antineoplastic Agents Language: En Journal: Cell Chem Biol Year: 2022 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos