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Mechanisms of circular RNA degradation.
Ren, Longxin; Jiang, Qingshan; Mo, Liyi; Tan, Lijie; Dong, Qifei; Meng, Lijuan; Yang, Nanyang; Li, Guoqing.
Affiliation
  • Ren L; The Hengyang Key Laboratory of Cellular Stress Biology, Institute of Cytology and Genetics, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • Jiang Q; Department of Otolaryngology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
  • Mo L; The Hengyang Key Laboratory of Cellular Stress Biology, Institute of Cytology and Genetics, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • Tan L; The Hengyang Key Laboratory of Cellular Stress Biology, Institute of Cytology and Genetics, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • Dong Q; The Hengyang Key Laboratory of Cellular Stress Biology, Institute of Cytology and Genetics, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • Meng L; Department of Ultrasonography, Second Affiliated Hospital, University of South China, Hengyang Hunan, 421001, China.
  • Yang N; The Hengyang Key Laboratory of Cellular Stress Biology, Institute of Cytology and Genetics, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. yangny204@usc.edu.cn.
  • Li G; The Hengyang Key Laboratory of Cellular Stress Biology, Institute of Cytology and Genetics, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. guoqingli@usc.edu.cn.
Commun Biol ; 5(1): 1355, 2022 12 09.
Article in En | MEDLINE | ID: mdl-36494488
ABSTRACT
Circular RNAs (CircRNAs) are a class of noncoding RNAs formed by backsplicing during cotranscriptional and posttranscriptional processes, and they widely exist in various organisms. CircRNAs have multiple biological functions and are associated with the occurrence and development of many diseases. While the biogenesis and biological function of circRNAs have been extensively studied, there are few studies on circRNA degradation and only a few pathways for specific circRNA degradation have been identified. Here we outline basic information about circRNAs, summarize the research on the circRNA degradation mechanisms and discusses where this field might head, hoping to provide some inspiration and guidance for scholars who aim to study the degradation of circRNAs.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA / RNA, Circular Language: En Journal: Commun Biol Year: 2022 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA / RNA, Circular Language: En Journal: Commun Biol Year: 2022 Document type: Article Affiliation country: China