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A large HIV gp41 construct with trimer-of-hairpins structure exhibits V2E mutation-dominant attenuation of vesicle fusion and helicity very similar to V2E attenuation of HIV fusion and infection and supports: (1) hairpin stabilization of membrane apposition with larger distance for V2E; and (2) V2E dominance by an antiparallel ß sheet with interleaved fusion peptide strands from two gp41 trimers.
Rokonujjaman, Md; Sahyouni, Abdulrazak; Wolfe, Robert; Jia, Lihui; Ghosh, Ujjayini; Weliky, David P.
Affiliation
  • Rokonujjaman M; Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA.
  • Sahyouni A; Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA.
  • Wolfe R; Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA.
  • Jia L; Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA.
  • Ghosh U; Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA.
  • Weliky DP; Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA. Electronic address: weliky@chemistry.msu.edu.
Biophys Chem ; 293: 106933, 2023 02.
Article in En | MEDLINE | ID: mdl-36508984
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / Membrane Fusion Limits: Humans Language: En Journal: Biophys Chem Year: 2023 Document type: Article Affiliation country: Estados Unidos Country of publication: Países Bajos
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / Membrane Fusion Limits: Humans Language: En Journal: Biophys Chem Year: 2023 Document type: Article Affiliation country: Estados Unidos Country of publication: Países Bajos