Host cell responses against the pseudomonal biofilm: A continued tale of host-pathogen interactions.
Microb Pathog
; 174: 105940, 2023 Jan.
Article
in En
| MEDLINE
| ID: mdl-36513294
ABSTRACT
In biofilm formation, pathogens within the bacterial community coordinate a cell-cell communication system called quorum sensing (QS). This is achieved through various signalling pathways that regulate bacterial virulence and host immune response. Here, we reviewed the host responses, key clinical implications, and novel therapeutic approaches against the biofilms of P. aeruginosa. Given the high degree of intrinsic antibiotic resistance and biofilm formation by the pathogen, the ensuing treatment complications could result in high morbidity and mortality rates worldwide. Notwithstanding the availability of intervention strategies, there remains a paucity of effective therapeutic options to control biofilmogenesis. This review discusses the basic understanding of QS-associated virulence factors and several key therapeutic interventions to foil the biofilm menace of P. aeruginosa.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biofilms
/
Anti-Bacterial Agents
Language:
En
Journal:
Microb Pathog
Journal subject:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Year:
2023
Document type:
Article