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PET/MR imaging of inflammation in atherosclerosis.
Senders, Max L; Calcagno, Claudia; Tawakol, Ahmed; Nahrendorf, Matthias; Mulder, Willem J M; Fayad, Zahi A.
Affiliation
  • Senders ML; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Calcagno C; Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
  • Tawakol A; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Nahrendorf M; Cardiology Division and Cardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Mulder WJM; Center for Systems Biology and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Fayad ZA; Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands. willem.mulder@radboudumc.nl.
Nat Biomed Eng ; 7(3): 202-220, 2023 03.
Article in En | MEDLINE | ID: mdl-36522465
ABSTRACT
Myocardial infarction, stroke, mental disorders, neurodegenerative processes, autoimmune diseases, cancer and the human immunodeficiency virus impact the haematopoietic system, which through immunity and inflammation may aggravate pre-existing atherosclerosis. The interplay between the haematopoietic system and its modulation of atherosclerosis has been studied by imaging the cardiovascular system and the activation of haematopoietic organs via scanners integrating positron emission tomography and resonance imaging (PET/MRI). In this Perspective, we review the applicability of integrated whole-body PET/MRI for the study of immune-mediated phenomena associated with haematopoietic activity and cardiovascular disease, and discuss the translational opportunities and challenges of the technology.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Atherosclerosis / Multimodal Imaging Limits: Humans Language: En Journal: Nat Biomed Eng Year: 2023 Document type: Article Affiliation country: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Atherosclerosis / Multimodal Imaging Limits: Humans Language: En Journal: Nat Biomed Eng Year: 2023 Document type: Article Affiliation country: Estados Unidos