Aging of the brain in bipolar disorder: Illness- and onset-related effects in cortical thickness and subcortical gray matter volume.
J Affect Disord
; 323: 875-883, 2023 02 15.
Article
in En
| MEDLINE
| ID: mdl-36526112
ABSTRACT
BACKGROUND:
Older adults with bipolar disorder (BD) have received little study, although they often have severe symptoms, treatment resistance and high suicide risk. Furthermore, a subset develops cognitive dysfunction for unknown reasons.METHODS:
Here, cortical thickness and subcortical gray matter volume were compared across individuals ages 40-79y 103 with BD ("later-onset" at ages ≥25y, n = 21; "early-onset" < 25y, n = 82) and healthy controls (HCs, n = 98).RESULTS:
Overall, those with BD showed lower prefrontal, cingulate, sensorimotor, parahippocampal, insula, temporal, parietal, and occipital cortical thickness (Cohen's d 0.4 to 0.8) and hippocampal, amygdalar, thalamic, and striatal gray matter volume (d 0.6 to 0.8). Later-onset BD showed negative relationships between age and parahippocampal, insular, temporal, parietal, and occipital cortical thickness, and hippocampal, thalamic and striatal volume (r -0.7 to -0.4). Suicide attempt history was associated with lower dorsolateral prefrontal cortical thickness (d = 0.5).LIMITATIONS:
The study used a cross-sectional design and the sample of those with a later-onset of BD was relatively modest.CONCLUSIONS:
Results support widespread gray matter decreases in older adults with BD, and also suggest a separable later-onset phenotype characterized by age-related gray matter reductions in regions subserving cognitive, emotional and perceptual processes. Moreover, the results are the first to demonstrate structural brain differences associated with a history of suicide attempts in older adults with BD.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bipolar Disorder
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
J Affect Disord
Year:
2023
Document type:
Article
Affiliation country:
Reino Unido