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Quercetin decreases cardiac hypertrophic mediators and maladaptive coronary arterial remodeling in renovascular hypertensive rats without improving cardiac function.
da Rocha, Eduardo Vieira; Falchetti, Francisco; Pernomian, Laena; de Mello, Marcela M Blascke; Parente, Juliana M; Nogueira, Renato C; Gomes, Beatriz Q; Bertozi, Giuliana; Sanches-Lopes, Jessica M; Tanus-Santos, José Eduardo; Castro, Michele M.
Affiliation
  • da Rocha EV; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av. Bandeirantes, Ribeirao Preto, SP, 3900, 14049-900, Brazil.
  • Falchetti F; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av. Bandeirantes, Ribeirao Preto, SP, 3900, 14049-900, Brazil.
  • Pernomian L; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av. Bandeirantes, Ribeirao Preto, SP, 3900, 14049-900, Brazil.
  • de Mello MMB; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av. Bandeirantes, Ribeirao Preto, SP, 3900, 14049-900, Brazil.
  • Parente JM; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av. Bandeirantes, Ribeirao Preto, SP, 3900, 14049-900, Brazil.
  • Nogueira RC; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av. Bandeirantes, Ribeirao Preto, SP, 3900, 14049-900, Brazil.
  • Gomes BQ; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av. Bandeirantes, Ribeirao Preto, SP, 3900, 14049-900, Brazil.
  • Bertozi G; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av. Bandeirantes, Ribeirao Preto, SP, 3900, 14049-900, Brazil.
  • Sanches-Lopes JM; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av. Bandeirantes, Ribeirao Preto, SP, 3900, 14049-900, Brazil.
  • Tanus-Santos JE; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av. Bandeirantes, Ribeirao Preto, SP, 3900, 14049-900, Brazil.
  • Castro MM; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av. Bandeirantes, Ribeirao Preto, SP, 3900, 14049-900, Brazil. castro@fmrp.usp.br.
Naunyn Schmiedebergs Arch Pharmacol ; 396(5): 939-949, 2023 05.
Article in En | MEDLINE | ID: mdl-36527481
Oxidative stress and MMP activity are found in the hearts and arteries in hypertension and contribute to the resulting hypertrophy and dysfunction. Quercetin is a flavonoid that reduces MMP-2 activity and ameliorates hypertrophic vascular remodeling of hypertension. The hypothesis is that treatment of hypertensive rats with quercetin ameliorates coronary maladaptive remodeling and decreases hypertrophic cardiac dysfunction by decreasing oxidative stress and MMP activity. Male Sprague-Dawley two-kidney, one-clip (2K1C) and Sham rats were treated with quercetin (10 mg/kg/day) or its vehicle for 8 weeks by gavage. Rats were analyzed at 10 weeks of hypertension. Systolic blood pressure (SBP) was examined by tail-cuff plethysmography. Cardiac left ventricles were used to determine MMP activity by in situ zymography and oxidative stress by dihydroethidium. Immunofluorescence was performed to detect transforming growth factor (TGF)-ß and nuclear factor kappa B (NFkB). Morphological analyses of heart and coronary arteries were done by H&E and picrosirius red, and cardiac function was measured by Langendorff. SBP was increased in 2K1C rats, and quercetin did not reduce it. However, quercetin decreased both oxidative stress and TGF-ß in the left ventricles of 2K1C rats. Quercetin also decreased the accentuated MMP activity in left ventricles and coronary arteries of 2K1C rats. Quercetin ameliorated hypertension-induced coronary arterial hypertrophic remodeling, although it did not reduce cardiac hypertrophic remodeling and dysfunction. Quercetin decreases cardiac oxidative stress and TGF-ß and MMP activity in addition to improving coronary remodeling, yet does not ameliorate cardiac dysfunction in 2K1C rats.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hypertension / Hypertension, Renovascular / Kidney Diseases Limits: Animals Language: En Journal: Naunyn Schmiedebergs Arch Pharmacol Year: 2023 Document type: Article Affiliation country: Brasil Country of publication: Alemania

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hypertension / Hypertension, Renovascular / Kidney Diseases Limits: Animals Language: En Journal: Naunyn Schmiedebergs Arch Pharmacol Year: 2023 Document type: Article Affiliation country: Brasil Country of publication: Alemania