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Safety and microbiological activity of phage therapy in persons with cystic fibrosis colonized with Pseudomonas aeruginosa: study protocol for a phase 1b/2, multicenter, randomized, double-blind, placebo-controlled trial.
Tamma, Pranita D; Souli, Maria; Billard, Michael; Campbell, Joseph; Conrad, Douglas; Ellison, Damon W; Evans, Beth; Evans, Scott R; Greenwood-Quaintance, Kerryl E; Filippov, Andrey A; Geres, Holly S; Hamasaki, Toshimitsu; Komarow, Lauren; Nikolich, Mikeljon P; Lodise, Thomas P; Nayak, Seema U; Norice-Tra, Carmelle; Patel, Robin; Pride, David; Russell, Janie; Van Tyne, Daria; Chambers, Henry F; FowlerJr, Vance G; Schooley, Robert T.
Affiliation
  • Tamma PD; Department of Pediatrics, Johns Hopkins University School of Medicine, 200 North Wolfe Street, Room 3149, Baltimore, MD, 21287, USA. ptamma1@jhmi.edu.
  • Souli M; Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
  • Billard M; Adaptive Phage Therapeutics, Inc., Gaithersburg, MD, USA.
  • Campbell J; National Institutes of Health, National Institute of Allergy and Infectious Diseases, Division of Microbiology and Infectious Diseases, Bethesda, MD, USA.
  • Conrad D; Department of Medicine, University of California San Diego, San Diego, CA, USA.
  • Ellison DW; Wound Infections Department, Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Evans B; Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
  • Evans SR; The Biostatistics Center, The George Washington University, Rockville, MD, USA.
  • Greenwood-Quaintance KE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, USA.
  • Filippov AA; Wound Infections Department, Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Geres HS; Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
  • Hamasaki T; The Biostatistics Center, The George Washington University, Rockville, MD, USA.
  • Komarow L; The Biostatistics Center, The George Washington University, Rockville, MD, USA.
  • Nikolich MP; Wound Infections Department, Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Lodise TP; Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, NY, USA.
  • Nayak SU; National Institutes of Health, National Institute of Allergy and Infectious Diseases, Division of Microbiology and Infectious Diseases, Bethesda, MD, USA.
  • Norice-Tra C; National Institutes of Health, National Institute of Allergy and Infectious Diseases, Division of Microbiology and Infectious Diseases, Bethesda, MD, USA.
  • Patel R; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, USA.
  • Pride D; Infectious Diseases and Occupational Medicine, Mayo Clinic, Rochester, MN, USA.
  • Russell J; Departments of Medicine and Pathology, University of California San Diego, San Diego, CA, USA.
  • Van Tyne D; National Institutes of Health, National Institute of Allergy and Infectious Diseases, Division of Microbiology and Infectious Diseases, Bethesda, MD, USA.
  • Chambers HF; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • FowlerJr VG; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
  • Schooley RT; Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
Trials ; 23(1): 1057, 2022 Dec 28.
Article in En | MEDLINE | ID: mdl-36578069
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cystic Fibrosis / Phage Therapy Type of study: Clinical_trials / Guideline Aspects: Patient_preference Limits: Adult / Humans Language: En Journal: Trials Journal subject: MEDICINA / TERAPEUTICA Year: 2022 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cystic Fibrosis / Phage Therapy Type of study: Clinical_trials / Guideline Aspects: Patient_preference Limits: Adult / Humans Language: En Journal: Trials Journal subject: MEDICINA / TERAPEUTICA Year: 2022 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido