Detailed radiosynthesis of [18 F]mG4P027 as a positron emission tomography radiotracer for mGluR4.
J Labelled Comp Radiopharm
; 66(2): 34-40, 2023 02.
Article
in En
| MEDLINE
| ID: mdl-36593743
ABSTRACT
We report here the detailed radiosynthesis of [18 F]mG4P027, a metabotropic glutamate receptor 4 (mGluR4) PET radiotracer, which showed superior properties to the currently reported mGluR4 radiotracers. The radiosynthesis in the automated system has been challenging, therefore we disclose here the major limiting factors for the synthesis via step-by-step examination. And we hope this thorough study will help its automation for human use in the future.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Metabotropic Glutamate
/
Radiopharmaceuticals
Limits:
Humans
Language:
En
Journal:
J Labelled Comp Radiopharm
Year:
2023
Document type:
Article
Affiliation country:
Estados Unidos