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Detailed radiosynthesis of [18 F]mG4P027 as a positron emission tomography radiotracer for mGluR4.
Wang, Junfeng; Moon, Sung-Hyun; Cleary, Michael B; Shoup, Timothy M; El Fakhri, Georges; Zhang, Zhaoda; Brownell, Anna-Liisa.
Affiliation
  • Wang J; Gordon Center for Medical Imaging, Massachusetts General Hospital &Department of Radiology, Harvard Medical School, Boston, MA, USA.
  • Moon SH; Gordon Center for Medical Imaging, Massachusetts General Hospital &Department of Radiology, Harvard Medical School, Boston, MA, USA.
  • Cleary MB; Martinos Center for Biomedical Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, Massachusetts, USA.
  • Shoup TM; Gordon Center for Medical Imaging, Massachusetts General Hospital &Department of Radiology, Harvard Medical School, Boston, MA, USA.
  • El Fakhri G; Gordon Center for Medical Imaging, Massachusetts General Hospital &Department of Radiology, Harvard Medical School, Boston, MA, USA.
  • Zhang Z; Martinos Center for Biomedical Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, Massachusetts, USA.
  • Brownell AL; Gordon Center for Medical Imaging, Massachusetts General Hospital &Department of Radiology, Harvard Medical School, Boston, MA, USA.
J Labelled Comp Radiopharm ; 66(2): 34-40, 2023 02.
Article in En | MEDLINE | ID: mdl-36593743
ABSTRACT
We report here the detailed radiosynthesis of [18 F]mG4P027, a metabotropic glutamate receptor 4 (mGluR4) PET radiotracer, which showed superior properties to the currently reported mGluR4 radiotracers. The radiosynthesis in the automated system has been challenging, therefore we disclose here the major limiting factors for the synthesis via step-by-step examination. And we hope this thorough study will help its automation for human use in the future.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Metabotropic Glutamate / Radiopharmaceuticals Limits: Humans Language: En Journal: J Labelled Comp Radiopharm Year: 2023 Document type: Article Affiliation country: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Metabotropic Glutamate / Radiopharmaceuticals Limits: Humans Language: En Journal: J Labelled Comp Radiopharm Year: 2023 Document type: Article Affiliation country: Estados Unidos