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The mRNA vaccine BNT162b2 demonstrates impaired TH1 immunogenicity in human elders in vitro and aged mice in vivo.
Brook, Byron; Fatou, Benoit; Kumar Checkervarty, Abhinav; Barman, Soumik; Sweitzer, Cali; Bosco, Anna-Nicole; Sherman, Amy C; Baden, Lindsey R; Morrocchi, Elena; Sanchez-Schmitz, Guzman; Palma, Paolo; Nanishi, Etsuro; O'Meara, Timothy R; McGrath, Marisa E; Frieman, Matthew B; Soni, Dheeraj; van Haren, Simon D; Ozonoff, Al; Diray-Arce, Joann; Steen, Hanno; Dowling, David J; Levy, Ofer.
Affiliation
  • Brook B; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
  • Fatou B; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
  • Kumar Checkervarty A; Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
  • Barman S; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
  • Sweitzer C; Prevention of Organ Failure (PROOF) Centre of Excellence, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
  • Bosco AN; UBC Centre for Heart Lung Innovation, Providence Research, St Paul's Hospital, Vancouver, BC, Canada.
  • Sherman AC; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
  • Baden LR; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
  • Morrocchi E; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
  • Sanchez-Schmitz G; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
  • Palma P; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
  • Nanishi E; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • O'Meara TR; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • McGrath ME; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
  • Frieman MB; Academic Department of Pediatrics (DPUO), Research Unit of Clinical Immunology and Vaccinology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
  • Soni D; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
  • van Haren SD; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
  • Ozonoff A; Bambino Gesù Children's Hospital, Rome, Italy.
  • Diray-Arce J; Chair of Pediatrics, University of Rome, Tor Vergata, Italy.
  • Steen H; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
  • Dowling DJ; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
  • Levy O; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
Res Sq ; 2022 Dec 21.
Article in En | MEDLINE | ID: mdl-36597547
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Res Sq Year: 2022 Document type: Article Affiliation country: Estados Unidos
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Res Sq Year: 2022 Document type: Article Affiliation country: Estados Unidos