Role of α-synuclein in microglia: autophagy and phagocytosis balance neuroinflammation in Parkinson's disease.
Inflamm Res
; 72(3): 443-462, 2023 Mar.
Article
in En
| MEDLINE
| ID: mdl-36598534
ABSTRACT
BACKGROUND:
Parkinson's disease (PD) is the second most common neurodegenerative disease, and is characterized by accumulation of α-synuclein (α-syn). Neuroinflammation driven by microglia is an important pathological manifestation of PD. α-Syn is a crucial marker of PD, and its accumulation leads to microglia M1-like phenotype polarization, activation of NLRP3 inflammasomes, and impaired autophagy and phagocytosis in microglia. Autophagy of microglia is related to degradation of α-syn and NLRP3 inflammasome blockage to relieve neuroinflammation. Microglial autophagy and phagocytosis of released α-syn or fragments from apoptotic neurons maintain homeostasis in the brain. A variety of PD-related genes such as LRRK2, GBA and DJ-1 also contribute to this stability process.OBJECTIVES:
Further studies are needed to determine how α-syn works in microglia.METHODS:
A keyword-based search was performed using the PubMed database for published articles.CONCLUSION:
In this review, we discuss the interaction between microglia and α-syn in PD pathogenesis and the possible mechanism of microglial autophagy and phagocytosis in α-syn clearance and inhibition of neuroinflammation. This may provide a novel insight into treatment of PD.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Neurodegenerative Diseases
Limits:
Humans
Language:
En
Journal:
Inflamm Res
Journal subject:
ALERGIA E IMUNOLOGIA
/
PATOLOGIA
Year:
2023
Document type:
Article
Affiliation country:
China