Validation of the 18F-FDG PET image biomarker model predicting late xerostomia after head and neck cancer radiotherapy.
Radiother Oncol
; 180: 109458, 2023 03.
Article
in En
| MEDLINE
| ID: mdl-36608769
ABSTRACT
BACKGROUND AND PURPOSE:
Previously, PET image biomarkers (PET-IBMs) - the 90th percentile standardized uptake value (P90-SUV) and the Mean SUV (Mean-SUV) of the contralateral parotid gland (cPG) - were identified as predictors for late-xerostomia following head and neck cancer (HNC) radiotherapy. The aim of the current study was to assess in an independent validation cohort whether these pre-treatment PET-IBM can improve late-xerostomia prediction compared to the prediction with baseline xerostomia and mean cPG dose alone. MATERIALS ANDMETHODS:
The prediction endpoint was patient-rated moderate-to-severe xerostomia at 12 months after radiotherapy. The PET-IBMs were extracted from pre-treatment 18 F-FDG PET images. The performance of the model (base model) with baseline xerostomia and mean cPG dose alone and models with additionally P90-SUV or Mean-SUV were tested in the current independent validation cohort. Specifically, model discrimination (area under the curve AUC) and calibration (calibration plot) were evaluated.RESULTS:
The current validation cohort consisted of 137 patients of which 40% developed moderate-to-severe xerostomia at 12 months. Both the PET-P90 model (AUCPET-P90 = 0.71) and the PET-Mean model (AUC PET-Mean = 0.70) performed well in the current validation cohort. Moreover, their performance were improved compared to the base model (AUCbase model= 0.68). The calibration plots showed a good fit of the prediction to the actual rates for all tested models.CONCLUSION:
PET-IBMs showed an improved prediction of late-xerostomia when added to the base model in this validation cohort. This contributed to the published hypothesis that PET-IBMs include individualized information and can serve as a pre-treatment risk factor for late-xerostomia.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Xerostomia
/
Head and Neck Neoplasms
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Radiother Oncol
Year:
2023
Document type:
Article