Relevance of enteroviruses in neonatal meningitis.
Enferm Infecc Microbiol Clin (Engl Ed)
; 42(1): 17-23, 2024 Jan.
Article
in En
| MEDLINE
| ID: mdl-36624031
ABSTRACT
INTRODUCTION:
Enterovirus (EV) infections are the most frequent infections in the neonatal period and in many cases lead to hospital admission of the newborn (NB). The aim of this study was to determine the incidence of EV in the etiology of neonatal meningitis and to define the clinical characteristics of newborns with EV meningitis. MATERIAL ANDMETHOD:
Retrospective observational cohort study. Including 91 NBs with meningitis and gestational age greater than 34 weeks gestational age (GA) attended in our center over a period of 16 years.RESULTS:
The percentage of NBs with EV meningitis was higher than that of NBs with bacterial meningitis (BM) and accounted for 78% (n=71). Half of the NBs with EV infection had a history of epidemic environment among their caregivers. Fever was present in 96% of cases as a clinical sign and, in general, sensory disturbances represented the main neurological alterations. Antibiotics (ATB) were given to 71.4% of patients with EV infection. Detection of EV in CSF samples showed a high sensitivity for the diagnosis of EV meningitis. The most frequently implicated EV types were echovirus 11, coxsackievirus B5, echovirus 18, 25 and 7.CONCLUSIONS:
The results of this series show that enterovirus infection is a common cause of neonatal meningitis. These data underline the importance of rapid EV testing of infants with suspected meningitis. This allows early diagnosis and reduces antibiotic treatment, hospitalization time and related costs.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Enterovirus
/
Enterovirus Infections
/
Infant, Newborn, Diseases
/
Meningitis, Viral
Type of study:
Observational_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Humans
/
Infant
/
Newborn
Language:
En
Journal:
Enferm Infecc Microbiol Clin (Engl Ed)
Year:
2024
Document type:
Article