The association of fatty liver and risk of hepatocellular carcinoma in HBV or HCV infected individuals: a systematic review and meta-analysis.
Expert Rev Gastroenterol Hepatol
; 17(2): 189-198, 2023 Feb.
Article
in En
| MEDLINE
| ID: mdl-36625022
ABSTRACT
BACKGROUND:
Fatty liver (FL) is reportedly a risk factor for hepatocellular carcinoma (HCC) in individuals affected with Hepatitis C (HCV) or B (HBV) virus. However, the results are contradictory, necessitating a meta-analysis. RESEARCH DESIGN ANDMETHODS:
Sixteen relevant studies involving 88,618 individuals were retrieved from the Cochrane Library, PubMed, MEDLINE, Embase, and Scopus databases from their inception to 10 December 2022. The hazard ratios (HR) and 95% confidence intervals (CI) were analyzed.RESULTS:
Liver biopsy-proven FL may be a significant risk factor for HCC in individuals affected with HBV (univariate analyses HR = 3.13, 95% CI = 1.69-5.79; multivariate analyses HR = 3.42, 95% CI = 0.83-14.09) as well as HCV (univariate analyses HR = 1.64, 95% CI = 0.93-2.90; multivariate analyses HR = 1.75, 95% CI = 1.02-3.00). However, the presence of FL confirmed using reasonable methods other than liver biopsy may not indicate a risk for HCC in HBV-infected individuals (univariate analyses HR = 0.90, 95% CI = 0.44-1.81; multivariate analyses HR = 0.69, 95% CI = 0.45-1.08).CONCLUSIONS:
Biopsy-proven FL may be a significant risk factor for HCC in HCV/HBV-infected individuals. Thus, such individuals should receive suitable interventions to prevent HCC formation or at least attenuate the risk of HCC.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hepatitis C
/
Carcinoma, Hepatocellular
/
Fatty Liver
/
Liver Neoplasms
Type of study:
Etiology_studies
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Expert Rev Gastroenterol Hepatol
Journal subject:
GASTROENTEROLOGIA
Year:
2023
Document type:
Article
Affiliation country:
China
Country of publication:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM