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Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development.
Rana, Vipin S; Kitsou, Chrysoula; Dutta, Shraboni; Ronzetti, Michael H; Zhang, Min; Bernard, Quentin; Smith, Alexis A; Tomás-Cortázar, Julen; Yang, Xiuli; Wu, Ming-Jie; Kepple, Oleksandra; Li, Weizhong; Dwyer, Jennifer E; Matias, Jaqueline; Baljinnyam, Bolormaa; Oliver, Jonathan D; Rajeevan, Nallakkandi; Pedra, Joao H F; Narasimhan, Sukanya; Wang, Yan; Munderloh, Ulrike; Fikrig, Erol; Simeonov, Anton; Anguita, Juan; Pal, Utpal.
Affiliation
  • Rana VS; Department of Veterinary Medicine, University of Maryland, College Park, MD, USA.
  • Kitsou C; Department of Veterinary Medicine, University of Maryland, College Park, MD, USA.
  • Dutta S; Department of Veterinary Medicine, University of Maryland, College Park, MD, USA.
  • Ronzetti MH; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
  • Zhang M; Department of Veterinary Medicine, University of Maryland, College Park, MD, USA.
  • Bernard Q; Department of Veterinary Medicine, University of Maryland, College Park, MD, USA.
  • Smith AA; Department of Veterinary Medicine, University of Maryland, College Park, MD, USA.
  • Tomás-Cortázar J; CIC bioGUNE-BRTA (Basque Research & Technology Alliance), 48160 Derio, Bizkaia, Spain.
  • Yang X; Department of Veterinary Medicine, University of Maryland, College Park, MD, USA.
  • Wu MJ; Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
  • Kepple O; Department of Veterinary Medicine, University of Maryland, College Park, MD, USA.
  • Li W; Department of Veterinary Medicine, University of Maryland, College Park, MD, USA.
  • Dwyer JE; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Matias J; Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
  • Baljinnyam B; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
  • Oliver JD; Department of Entomology, University of Minnesota, Minneapolis, MN, USA.
  • Rajeevan N; Yale Center for Medical Informatics, Yale University School of Medicine, New Haven, CT, USA.
  • Pedra JHF; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Narasimhan S; Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
  • Wang Y; Mass Spectrometry Facility, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
  • Munderloh U; Department of Entomology, University of Minnesota, Minneapolis, MN, USA.
  • Fikrig E; Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
  • Simeonov A; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
  • Anguita J; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
  • Pal U; CIC bioGUNE-BRTA (Basque Research & Technology Alliance), 48160 Derio, Bizkaia, Spain.
Science ; 379(6628): eabl3837, 2023 01 13.
Article in En | MEDLINE | ID: mdl-36634189
ABSTRACT
Ancestral signaling pathways serve critical roles in metazoan development, physiology, and immunity. We report an evolutionary interspecies communication pathway involving a central Ixodes scapularis tick receptor termed Dome1, which acquired a mammalian cytokine receptor motif exhibiting high affinity for interferon-gamma (IFN-γ). Host-derived IFN-γ facilitates Dome1-mediated activation of the Ixodes JAK-STAT pathway. This accelerates tick blood meal acquisition and development while upregulating antimicrobial components. The Dome1-JAK-STAT pathway, which exists in most Ixodid tick genomes, regulates the regeneration and proliferation of gut cells-including stem cells-and dictates metamorphosis through the Hedgehog and Notch-Delta networks, ultimately affecting Ixodes vectorial competence. We highlight the evolutionary dependence of I. scapularis on mammalian hosts through cross-species signaling mechanisms that dually influence arthropod immunity and development.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arachnid Vectors / Receptors, Cytokine / Ixodes / STAT Transcription Factors / Janus Kinases / Host-Parasite Interactions Limits: Animals Language: En Journal: Science Year: 2023 Document type: Article Affiliation country: Estados Unidos
Fulltext
Add to My VHL
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arachnid Vectors / Receptors, Cytokine / Ixodes / STAT Transcription Factors / Janus Kinases / Host-Parasite Interactions Limits: Animals Language: En Journal: Science Year: 2023 Document type: Article Affiliation country: Estados Unidos