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Synthesis of Bis(3-indolyl)methanes Mediated by Potassium tert-Butoxide.
Santos, A Sofia; Ferro, Rita D; Viduedo, Nuno; Maia, Luísa B; Silva, Artur M S; Marques, M Manuel B.
Affiliation
  • Santos AS; LAQV@REQUIMTE, Departamento de Química, NOVA School of Science and Technology, Universidade Nova de Lisboa, Campus de Caparica, 2829-516, Caparica, Portugal.
  • Ferro RD; LAQV@REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal.
  • Viduedo N; LAQV@REQUIMTE, Departamento de Química, NOVA School of Science and Technology, Universidade Nova de Lisboa, Campus de Caparica, 2829-516, Caparica, Portugal.
  • Maia LB; LAQV@REQUIMTE, Departamento de Química, NOVA School of Science and Technology, Universidade Nova de Lisboa, Campus de Caparica, 2829-516, Caparica, Portugal.
  • Silva AMS; LAQV@REQUIMTE, Departamento de Química, NOVA School of Science and Technology, Universidade Nova de Lisboa, Campus de Caparica, 2829-516, Caparica, Portugal.
  • Marques MMB; LAQV@REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal.
ChemistryOpen ; 12(1): e202200265, 2023 01.
Article in En | MEDLINE | ID: mdl-36650736
ABSTRACT
The indole moiety is an important N-heterocycle found in natural products, and a key structural component of many value-added chemicals including pharmaceuticals. In particular, bis(3-indolyl)methanes (BIMs) are an important subgroup of indoles, composed of two indole units. Herein, we report the development of a simple method to access BIMs derivatives in yields of up to 77 % by exploiting a tBuOK-mediated coupling reaction of indoles and benzyl alcohols.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Butanols / Methane Language: En Journal: ChemistryOpen Year: 2023 Document type: Article Affiliation country: Portugal
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Butanols / Methane Language: En Journal: ChemistryOpen Year: 2023 Document type: Article Affiliation country: Portugal