Content analysis and drug safety evaluation of four furanocoumarins in six pomelos produced in China.
Nat Prod Res
; 37(23): 3984-3993, 2023.
Article
in En
| MEDLINE
| ID: mdl-36657401
ABSTRACT
The content of 4 6',7'-dihydroxybergamottin (DHB), bergamottin, isoimperatorin and epoxybergamottin of six pomelos produced in China were detected by High-performance liquid chromatography-diode array detection and their safety of related medicines was evaluated by inhibition of medium concentration (IC50) of cytochrome oxidases CYP450-like. The results showed that the total content of the four furanocoumarins in these pomelo juices from high to low in order was Guanximi pomelo > Liangping pomelo > Pinghemi pomelo > grapefruit > Huyou > Shatian pomelo. The concentration of isoimperatorin in grapefruit, DHB, bergamottinand and isoimperatorin in Liangping, bergamottin and epoxybergamottin in Pinghemi and all the four furanocoumarins in Guanximi were exceeded the corresponding IC50; although Huyou and Shatian contained some furanocoumarins, they did not exceed IC50. Therefore, when taking drugs metabolised by CYP450-like enzymes, Guanximi, Liangping, Pinghemi, and grapefruit should be avoided to consume, but it is relatively safe to eat Huyou and Shatian.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Furocoumarins
/
Citrus paradisi
Country/Region as subject:
Asia
Language:
En
Journal:
Nat Prod Res
Year:
2023
Document type:
Article
Affiliation country:
China