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Pharmacological inhibition of MEK1/2 signaling disrupts bile acid metabolism through loss of Shp and enhanced Cyp7a1 expression.
Verzijl, Cristy R C; van de Peppel, Ivo P; Eilers, Roos E; Bloks, Vincent W; Wolters, Justina C; Koehorst, Martijn; Kloosterhuis, Niels J; Havinga, Rick; Jalving, Mathilde; Struik, Dicky; Jonker, Johan W.
Affiliation
  • Verzijl CRC; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • van de Peppel IP; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Eilers RE; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Bloks VW; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Wolters JC; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Koehorst M; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9713 Groningen, GZ, The Netherlands.
  • Kloosterhuis NJ; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Havinga R; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Jalving M; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Struik D; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Jonker JW; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: j.w.jonker@umcg.nl.
Biomed Pharmacother ; 159: 114270, 2023 Mar.
Article in En | MEDLINE | ID: mdl-36680812
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Cytoplasmic and Nuclear / Liver Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Biomed Pharmacother Year: 2023 Document type: Article Affiliation country: Países Bajos Country of publication: Francia
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Cytoplasmic and Nuclear / Liver Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Biomed Pharmacother Year: 2023 Document type: Article Affiliation country: Países Bajos Country of publication: Francia