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Global hypomethylation in childhood asthma identified by genome-wide DNA-methylation sequencing preferentially affects enhancer regions.
Thürmann, Loreen; Klös, Matthias; Mackowiak, Sebastian D; Bieg, Matthias; Bauer, Tobias; Ishaque, Naveed; Messingschlager, Marey; Herrmann, Carl; Röder, Stefan; Bauer, Mario; Schäuble, Sascha; Faessler, Erik; Hahn, Udo; Weichenhan, Dieter; Mücke, Oliver; Plass, Christoph; Borte, Michael; von Mutius, Erika; Stangl, Gabriele I; Lauener, Roger; Karvonen, Anne M; Divaret-Chauveau, Amandine; Riedler, Josef; Heinrich, Joachim; Standl, Marie; von Berg, Andrea; Schaaf, Beate; Herberth, Gunda; Kabesch, Michael; Eils, Roland; Trump, Saskia; Lehmann, Irina.
Affiliation
  • Thürmann L; Associated Member of the German Center for Lung Research, Unit for Molecular Epidemiology, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Klös M; Associated Member of the German Center for Lung Research, Unit for Molecular Epidemiology, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Mackowiak SD; Associated Member of the German Center for Lung Research, Center for Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Bieg M; Associated Member of the German Center for Lung Research, Center for Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Bauer T; German Cancer Research Center (DKFZ), Division of Theoretical Bioinformatics and Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany.
  • Ishaque N; Associated Member of the German Center for Lung Research, Center for Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Messingschlager M; Associated Member of the German Center for Lung Research, Unit for Molecular Epidemiology, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Herrmann C; Health Data Science Unit, Heidelberg University Hospital, Heidelberg, Germany.
  • Röder S; Department of Environmental Immunology, Helmholtz Centre for Environmental Research (UFZ), Leipzig, Germany.
  • Bauer M; Department of Environmental Immunology, Helmholtz Centre for Environmental Research (UFZ), Leipzig, Germany.
  • Schäuble S; Friedrich-Schiller-University Jena, Jena University Language & Information Engineering (JULIE) Lab, Jena, Germany.
  • Faessler E; Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, Systems Biology and Bioinformatics Unit, Jena, Germany.
  • Hahn U; Friedrich-Schiller-University Jena, Jena University Language & Information Engineering (JULIE) Lab, Jena, Germany.
  • Weichenhan D; Friedrich-Schiller-University Jena, Jena University Language & Information Engineering (JULIE) Lab, Jena, Germany.
  • Mücke O; Division of Cancer Epigenetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Plass C; Division of Cancer Epigenetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Borte M; Division of Cancer Epigenetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • von Mutius E; German Center for Lung Research (DZL), Heidelberg, Munich, Germany.
  • Stangl GI; Children's Hospital, Municipal Hospital "St. Georg", Leipzig, Germany.
  • Lauener R; German Center for Lung Research (DZL), Heidelberg, Munich, Germany.
  • Karvonen AM; Dr. von Hauner Children's Hospital, Ludwig Maximilian University Munich, Munich, Germany.
  • Divaret-Chauveau A; Helmholtz Zentrum München-German Research Center for Environmental Health, Institute for Asthma and Allergy Prevention, Neuherberg, Germany.
  • Riedler J; Martin Luther University Halle-Wittenberg, Institute of Agricultural and Nutritional Sciences, Halle (Saale), Germany.
  • Heinrich J; Children's Hospital of Eastern Switzerland, St. Gallen, Switzerland.
  • Standl M; Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland.
  • von Berg A; Pediatric Allergy Department, Children's Hospital, University Hospital of Nancy, Vandoeuvre les Nancy, France.
  • Schaaf B; UMR 6249 Chrono-Environment, Centre National de la Recherche Scientifique and University of Franche-Comté, Besançon, France.
  • Herberth G; EA3450 Development, Adaptation and Handicap, University of Lorraine, Nancy, France.
  • Kabesch M; Children's Hospital, Schwarzach, Austria.
  • Eils R; German Center for Lung Research (DZL), Heidelberg, Munich, Germany.
  • Trump S; Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU, Munich, Germany.
  • Lehmann I; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Allergy ; 78(6): 1489-1506, 2023 06.
Article in En | MEDLINE | ID: mdl-36704932
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Epigenesis, Genetic Limits: Female / Humans / Pregnancy Language: En Journal: Allergy Year: 2023 Document type: Article Affiliation country: Alemania Country of publication: Dinamarca
Fulltext
Add to My VHL
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Epigenesis, Genetic Limits: Female / Humans / Pregnancy Language: En Journal: Allergy Year: 2023 Document type: Article Affiliation country: Alemania Country of publication: Dinamarca