Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity.
Sci Rep
; 13(1): 2042, 2023 02 04.
Article
in En
| MEDLINE
| ID: mdl-36739463
ABSTRACT
Individuals infected by SARS-CoV-2 are at risk of developing neurological-related post-acute disorders. Disputed epidemiological data indicated nicotine may reduce the severity of infection. Here we find exposure to nicotine in drinking water does not alter the moribundity of hACE2 mice. However, pre-exposure to nicotine decreased the likelihood of SARS-CoV-2 RNA expression and pathology in the brain. These results suggest mechanisms involving targets of nicotine could be leveraged to prevent the neurovirulence of SARS-CoV-2.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
COVID-19
/
Nervous System Diseases
Limits:
Animals
Language:
En
Journal:
Sci Rep
Year:
2023
Document type:
Article
Affiliation country:
Estados Unidos