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Dihydroartemisinin engages liver fatty acid binding protein and suppresses metastatic hepatocellular carcinoma growth.
Ruan, Mei-Ling; Liu, Yungen; Zhang, Chunlei; Mao, Xiaowen; Hu, Di; Lok, Chun-Nam; Yam, Judy Wai Ping; Che, Chi-Ming.
Affiliation
  • Ruan ML; National Key Laboratory of Green Pesticide, College of Chemistry, Central China Normal University, Wuhan, 430079, P. R. China.
  • Liu Y; State Key Laboratory of Synthetic Chemistry, and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China. cmche@hku.hk.
  • Zhang C; Laboratory for Synthetic Chemistry and Chemical Biology Limited, Hong Kong Science Park, Shatin, Hong Kong, P. R. China.
  • Mao X; Department of Chemistry, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, P. R. China.
  • Hu D; State Key Laboratory of Synthetic Chemistry, and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China. cmche@hku.hk.
  • Lok CN; Laboratory for Synthetic Chemistry and Chemical Biology Limited, Hong Kong Science Park, Shatin, Hong Kong, P. R. China.
  • Yam JWP; Department of Pathology, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China.
  • Che CM; State Key Laboratory of Synthetic Chemistry, and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China. cmche@hku.hk.
Chem Commun (Camb) ; 59(19): 2747-2750, 2023 Mar 02.
Article in En | MEDLINE | ID: mdl-36757177
ABSTRACT
Dihydroartemisinin non-covalently binds liver fatty acid binding protein (FABP1) with micromolar affinity, acts as a FABP1-dependent peroxisome proliferator-activated receptor alpha agonist and inhibits metastatic hepatocellular carcinoma growth.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Artemisinins / Liver Neoplasms Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2023 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Artemisinins / Liver Neoplasms Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2023 Document type: Article