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Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification.
Pavlic, Angelina; Poelman, Hessel; Wasilewski, Grzegorz; Wichapong, Kanin; Lux, Petra; Maassen, Cecile; Lutgens, Esther; Schurgers, Leon J; Reutelingsperger, Chris P; Nicolaes, Gerry A F.
Affiliation
  • Pavlic A; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 MD Maastricht, The Netherlands.
  • Poelman H; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 MD Maastricht, The Netherlands.
  • Wasilewski G; Amsterdam UMC, University of Amsterdam, Medical Biochemistry, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
  • Wichapong K; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 MD Maastricht, The Netherlands.
  • Lux P; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 MD Maastricht, The Netherlands.
  • Maassen C; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 MD Maastricht, The Netherlands.
  • Lutgens E; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 MD Maastricht, The Netherlands.
  • Schurgers LJ; Amsterdam UMC, University of Amsterdam, Medical Biochemistry, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
  • Reutelingsperger CP; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians Universität, 80539 München, Germany.
  • Nicolaes GAF; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, 80539 Munich, Germany.
Int J Mol Sci ; 24(3)2023 Jan 19.
Article in En | MEDLINE | ID: mdl-36768348
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Exosomes / Vascular Calcification / Muscle, Smooth, Vascular Type of study: Prognostic_studies Limits: Humans Language: En Journal: Int J Mol Sci Year: 2023 Document type: Article Affiliation country: Países Bajos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Exosomes / Vascular Calcification / Muscle, Smooth, Vascular Type of study: Prognostic_studies Limits: Humans Language: En Journal: Int J Mol Sci Year: 2023 Document type: Article Affiliation country: Países Bajos