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Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity.
Shchegravina, E S; Usova, S D; Baev, D S; Mozhaitsev, E S; Shcherbakov, D N; Belenkaya, S V; Volosnikova, E A; Chirkova, V Yu; Sharlaeva, E A; Svirshchevskaya, E V; Fonareva, I P; Sitdikova, A R; Salakhutdinov, N F; Yarovaya, O I; Fedorov, A Yu.
Affiliation
  • Shchegravina ES; Lobachevsky State University of Nizhny Novgorod, k. 2, 23 prosp. Gagarina, 603950 Nizhny Novgorod, Russian Federation.
  • Usova SD; Lobachevsky State University of Nizhny Novgorod, k. 2, 23 prosp. Gagarina, 603950 Nizhny Novgorod, Russian Federation.
  • Baev DS; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Akad. Lavrent'eva, 630090 Novosibirsk, Russian Federation.
  • Mozhaitsev ES; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Akad. Lavrent'eva, 630090 Novosibirsk, Russian Federation.
  • Shcherbakov DN; State Scientific Center of Virology and Biotechnology "Vector", 630559 Koltsovo, Novosibirsk Region, Russian Federation.
  • Belenkaya SV; State Scientific Center of Virology and Biotechnology "Vector", 630559 Koltsovo, Novosibirsk Region, Russian Federation.
  • Volosnikova EA; Novosibirsk State University, 1 ul. Pirogova, 630090 Novosibirsk, Russian Federation.
  • Chirkova VY; State Scientific Center of Virology and Biotechnology "Vector", 630559 Koltsovo, Novosibirsk Region, Russian Federation.
  • Sharlaeva EA; Altai State University, 61 Leninsky prosp., 656049 Barnaul, Russian Federation.
  • Svirshchevskaya EV; Altai State University, 61 Leninsky prosp., 656049 Barnaul, Russian Federation.
  • Fonareva IP; Department of Immunology, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 ul. Miklukho-Maklaya, 117997 Moscow, Russian Federation.
  • Sitdikova AR; Lobachevsky State University of Nizhny Novgorod, k. 2, 23 prosp. Gagarina, 603950 Nizhny Novgorod, Russian Federation.
  • Salakhutdinov NF; Lobachevsky State University of Nizhny Novgorod, k. 2, 23 prosp. Gagarina, 603950 Nizhny Novgorod, Russian Federation.
  • Yarovaya OI; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Akad. Lavrent'eva, 630090 Novosibirsk, Russian Federation.
  • Fedorov AY; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Akad. Lavrent'eva, 630090 Novosibirsk, Russian Federation.
Russ Chem Bull ; 72(1): 248-262, 2023.
Article in En | MEDLINE | ID: mdl-36817557
ABSTRACT
Conjugates of the natural alkaloid (aR,7S)-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic properties of the agents against different cell lines and the ability to inhibit the main viral protease 3CLPro were studied.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Russ Chem Bull Year: 2023 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Russ Chem Bull Year: 2023 Document type: Article