Effect of Protein Intake Early in Life on Kidney Volume and Blood Pressure at 11 Years of Age.
Nutrients
; 15(4)2023 Feb 09.
Article
in En
| MEDLINE
| ID: mdl-36839233
ABSTRACT
High protein intake has been associated with kidney hypertrophy, which is usually reversible; however, when it occurs early in life, it could lead to cell programming with a long-lasting effect. This study aimed to assess whether higher protein ingestion early in life has a persistent effect on kidney volume at 11 years of age, as well as its influence on blood pressure. This is a secondary analysis of a randomized control trial that compared the growth of infants fed with a higher-protein formula versus those fed with a lower-protein formula, with a control group of breastfed infants. Renal ultrasound and anthropometric measurements were assessed at 6 months and 11 years of age. At 11 years, urinary protein, albumin and creatinine, and blood pressure were measured in 232 children. Feeding with a higher-protein formula was associated with a larger kidney volume (ß = 8.71, 95%CI 0.09-17.33, p = 0.048) and higher systolic blood pressure (ß = 3.43, 95%CI 0.78-6.08, p = 0.011) at 11 years of age. Microalbuminuria was detected in 7% of the patients, with no differences among groups (p = 0.56). The effect of increased protein ingestion early in life may condition kidney volume and blood pressure in later childhood.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Pressure
/
Dietary Proteins
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Infant Nutritional Physiological Phenomena
/
Kidney
Type of study:
Clinical_trials
Limits:
Child
/
Female
/
Humans
/
Infant
Language:
En
Journal:
Nutrients
Year:
2023
Document type:
Article
Affiliation country:
España