Impaired oxygen extraction and adaptation of intracellular energy metabolism in cerebral small vessel disease.

Reiländer, Annemarie; Pilatus, Ulrich; Schüre, Jan-Rüdiger; Shrestha, Manoj; Deichmann, Ralf; Nöth, Ulrike; Hattingen, Elke; Gracien, René-Maxime; Wagner, Marlies; Seiler, Alexander

Reiländer, Annemarie; Pilatus, Ulrich; Schüre, Jan-Rüdiger; Shrestha, Manoj; Deichmann, Ralf; Nöth, Ulrike; Hattingen, Elke; Gracien, René-Maxime; Wagner, Marlies; Seiler, Alexander.

Affiliation

Reiländer A; Department of Neurology, Goethe University Hospital Frankfurt, Schleusenweg 2-16, Frankfurt 60528, Germany.
Pilatus U; Brain Imaging Center, Goethe University Hospital Frankfurt, Frankfurt Germany.
Schüre JR; Institute of Neuroradiology, Goethe University Hospital Frankfurt, Frankfurt Germany.
Shrestha M; Institute of Neuroradiology, Goethe University Hospital Frankfurt, Frankfurt Germany.
Deichmann R; Brain Imaging Center, Goethe University Hospital Frankfurt, Frankfurt Germany.
Nöth U; Brain Imaging Center, Goethe University Hospital Frankfurt, Frankfurt Germany.
Hattingen E; Brain Imaging Center, Goethe University Hospital Frankfurt, Frankfurt Germany.
Gracien RM; Institute of Neuroradiology, Goethe University Hospital Frankfurt, Frankfurt Germany.
Wagner M; Department of Neurology, Goethe University Hospital Frankfurt, Schleusenweg 2-16, Frankfurt 60528, Germany.
Seiler A; Brain Imaging Center, Goethe University Hospital Frankfurt, Frankfurt Germany.

Cereb Circ Cogn Behav ; 4: 100162, 2023.

Article in En | MEDLINE | ID: mdl-36851996

Key words

BBB, blood-brain barrier; CBF, cerebral blood flow; CBV, cerebral blood volume; CMRO2, Cerebral metabolic rate of oxygen; Cellular energy metabolism; DTI, diffusion tensor imaging; GE, gradient echo; Hb, hemoglobin; ICA, internal carotid artery; MR spectroscopy; MRI, magnetic resonance imaging; MRS, magnetic resonance spectroscopy; MRSI, magnetic resonance spectroscopic imaging; Microstructural impairment; NAWM, normal-appearing white matter; OEF, oxygen extraction fraction; Oxygen extraction fraction; PI, Pulsatility index; RF, radio frequency; SVD, cerebral small vessel disease; Small vessel disease; TR, repetition time; WM, white matter; WMH, white matter hyperintensities; pHi, intracellular pH; quantitative MRI

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Cereb Circ Cogn Behav Year: 2023 Document type: Article Affiliation country: Alemania Country of publication: Países Bajos

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