A Novel Ubiquitin Complex Regulates Aneuploid Epithelial Tumors by Moderating an Integrated Stress Response.
Cancer Discov
; 13(3): 535-537, 2023 03 01.
Article
in En
| MEDLINE
| ID: mdl-36855916
ABSTRACT
SUMMARY:
Tumor fitness coessentiality gene analysis that aims to expand the repertoire of druggable targets reveals a novel ubiquitin ligase complex, the BICR6 module. Along with the other complex members (UBA6, KCMF1, and UBR4), BIRC6 selectively contributes to the survival of a subset of epithelial tumors with a high degree of aneuploidy by ubiquitinating and suppressing HRI, a component of the integrated stress response adaptive pathway. See related article by Cervia et al., p. 766 (2).
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma
/
Ubiquitin
Limits:
Humans
Language:
En
Journal:
Cancer Discov
Year:
2023
Document type:
Article