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The Vagus Nerve Mediates Gut-Brain Response to Duodenal Nutrient Administration.
Ross, Robert C; He, Yanlin; Townsend, R Leigh; Schauer, Philip R; Berthoud, Hans-Rudolph; Morrison, Christopher D; Albaugh, Vance L.
Affiliation
  • Ross RC; Translational and Integrative Gastrointestinal and Endocrine Research Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
  • He Y; Neurobiology of Nutrition & Metabolism Department, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
  • Townsend RL; Translational and Integrative Gastrointestinal and Endocrine Research Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
  • Schauer PR; Metamor Institute, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
  • Berthoud HR; Neurobiology of Nutrition & Metabolism Department, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
  • Morrison CD; Neurobiology of Nutrition & Metabolism Department, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
  • Albaugh VL; Translational and Integrative Gastrointestinal and Endocrine Research Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Am Surg ; 89(8): 3600-3602, 2023 Aug.
Article in En | MEDLINE | ID: mdl-36867071
ABSTRACT

BACKGROUND:

Obesity contributes significant disease burden worldwide, including diabetes, cardiovascular disease, and cancer. While bariatric surgery is the most effective and durable obesity treatment, the mechanisms underlying its effects remain unknown. Although neuro-hormonal mechanisms have been suspected to mediate at least some of the gut-brain axis changes following bariatric surgery, studies examining the intestine and its regionally specific post-gastric alterations to these signals remain unclear. MATERIALS AND

METHODS:

Vagus nerve recording was performed following the implantation of duodenal feeding tubes in mice. Testing conditions and measurements were made under anesthesia during baseline, nutrient or vehicle solution delivery, and post-delivery. Solutions tested included water, glucose, glucose with an inhibitor of glucose absorption (phlorizin), and a hydrolyzed protein solution.

RESULTS:

Vagus nerve signaling was detectable from the duodenum and exhibited stable baseline activity without responding to osmotic pressure gradients. Duodenal-delivered glucose and protein robustly increased vagus nerve signaling, but increased signaling was abolished during the co-administration of glucose and phlorizin.

DISCUSSION:

Gut-brain communication via the vagus nerve emanating from the duodenum is nutrient sensitive and easily measurable in mice. Examination of these signaling pathways may help elucidate how the nutrient signals from the intestine are altered when applied to obesity and bariatric surgery mouse models. Future studies will address quantifying the changes in neuroendocrine nutrient signals in health and obesity, with specific emphasis on identifying the changes associated with bariatric surgery and other gastrointestinal surgery.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phlorhizin / Bariatric Surgery Limits: Animals Language: En Journal: Am Surg Year: 2023 Document type: Article Affiliation country: Estados Unidos Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phlorhizin / Bariatric Surgery Limits: Animals Language: En Journal: Am Surg Year: 2023 Document type: Article Affiliation country: Estados Unidos Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA