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Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study.
Thorsen, Steffen U; Liu, Xiang; Kataria, Yachana; Mandrup-Poulsen, Thomas; Kaur, Simranjeet; Uusitalo, Ulla; Virtanen, Suvi M; Norris, Jill M; Rewers, Marian; Hagopian, William; Yang, Jimin; She, Jin-Xiong; Akolkar, Beena; Rich, Stephen; Aronsson, Carin Andrén; Lernmark, Åke; Ziegler, Anette-Gabriele; Toppari, Jorma; Krischer, Jeffrey; Parikh, Hemang M; Ellervik, Christina; Svensson, Jannet.
Affiliation
  • Thorsen SU; 1Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Liu X; 2Steno Diabetes Center Copenhagen, Copenhagen University Hospital, Herlev, Herlev, Denmark.
  • Kataria Y; 3Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL.
  • Mandrup-Poulsen T; 4Department of Pathology and Laboratory Medicine, Boston University, Boston, MA.
  • Kaur S; 1Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Uusitalo U; 2Steno Diabetes Center Copenhagen, Copenhagen University Hospital, Herlev, Herlev, Denmark.
  • Virtanen SM; 3Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL.
  • Norris JM; 5Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Rewers M; 6Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, Finland.
  • Hagopian W; 7Center for Child Health Research, Tampere University and University Hospital and Research, Development and Innovation Centre, Tampere University Hospital, Tampere, Finland.
  • Yang J; 8Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO.
  • She JX; 9Pacific Northwest Research Institute, Seattle, WA.
  • Akolkar B; 10Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO.
  • Rich S; 11Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA.
  • Aronsson CA; 11Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA.
  • Lernmark Å; 12National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.
  • Ziegler AG; 13Center for Public Health Genomics and Department of Public Health Sciences, University of Virginia, Charlottesville, VA.
  • Toppari J; 14Department of Clinical Sciences, Lund University Clinical Research Centre, Skåne University Hospital, Malmö, Sweden.
  • Krischer J; 14Department of Clinical Sciences, Lund University Clinical Research Centre, Skåne University Hospital, Malmö, Sweden.
  • Parikh HM; 15Institute of Diabetes Research, Helmholtz Zentrum München, and Klinikum rechts der Isar, Technische Universität München, and Forschergruppe Diabetes e.V., Neuherberg, Germany.
  • Ellervik C; 16Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, and Centre for Population Health Research, University of Turku, and Department of Pediatrics, Turku University Hospital, Turku, Finland.
  • Svensson J; 3Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL.
Diabetes Care ; 46(5): 1014-1018, 2023 05 01.
Article in En | MEDLINE | ID: mdl-36867433
ABSTRACT

OBJECTIVE:

To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D). RESEARCH DESIGN AND

METHODS:

In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron.

RESULTS:

We found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake.

CONCLUSIONS:

Iron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Islets of Langerhans / Iron Overload / Diabetes Mellitus, Type 1 Type of study: Etiology_studies / Risk_factors_studies Limits: Child / Humans / Infant Language: En Journal: Diabetes Care Year: 2023 Document type: Article Affiliation country: Dinamarca
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Islets of Langerhans / Iron Overload / Diabetes Mellitus, Type 1 Type of study: Etiology_studies / Risk_factors_studies Limits: Child / Humans / Infant Language: En Journal: Diabetes Care Year: 2023 Document type: Article Affiliation country: Dinamarca